Age Dependent Accumulation Patterns of Advanced Glycation End Product Receptor (RAGE) Ligands and Binding Intensities Between RAGE and Its Ligands Differ in the Liver, Kidney, and Skeletal Muscle

Overview

Journal Immun Ageing

Publisher Biomed Central

Specialty Geriatrics

Date 2017 Jun 9

PMID 28592983

Citations 14

Authors

Myeongjoo Son

Wook-Jin Chung

Seyeon Oh

Hyosang Ahn

Chang Hu Choi

Suntaek Hong

Kook Yang Park

Kuk Hui Son

Kyunghee Byun

Affiliations

Soon will be listed here.

Abstract

Background: Much evidence indicates receptor for advanced glycation end products (RAGE) related inflammation play essential roles during aging. However, the majority of studies have focused on advanced glycation end products (AGEs) and not on other RAGE ligands. In the present study, the authors evaluated whether the accumulation of RAGE ligands and binding intensities between RAGE and its ligands differ in kidney, liver, and skeletal muscle during aging.

Results: In C57BL/6 N mice aged 12 weeks, 12 months, and 22 months, ligands accumulation, binding intensities between RAGE and its ligands, activated macrophage infiltration, M1/M2 macrophage expression, glyoxalase-1expression, and signal pathways related to inflammation were evaluated. The RAGE ligands age-associated accumulation patterns were found to be organ dependent. Binding intensities between RAGE and its ligands in kidney and liver increased with age, but those in skeletal muscle were unchanged. Infiltration of activated macrophages in kidney and liver increased with age, but infiltration in the skeletal muscle was unchanged. M1 expression increased and M2 and glyoxalase-1 expression decreased with age in kidney and liver, but their expressions in skeletal muscle were not changed.

Conclusion: These findings indicate patterns of RAGE ligands accumulation, RAGE/ligands binding intensities, or inflammation markers changes during aging are organs dependent.

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