Assessment of Tolerance to the Effects of Methamphetamine on Daytime and Nighttime Activity Evaluated with Actigraphy in Rhesus Monkeys

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 2017 Jun 8

PMID 28589263

Citations 6

Authors

Lais F Berro

Monica L Andersen

Leonard L Howell

Affiliations

Soon will be listed here.

Abstract

Rationale: Methamphetamine is one of the most largely consumed illicit drugs, and its use is associated with abuse liability and several adverse health effects, such as sleep impairment. Importantly, sleep quality can influence addiction treatment outcomes. Evidence suggests that tolerance can develop to the sleep-disrupting effects of stimulant drugs.

Objective: The aim of the present study was to investigate the development of tolerance to the actigraphy-based sleep-disrupting and stimulant effects of methamphetamine self-administration in rhesus monkeys.

Methods: Methamphetamine (0.03 mg/kg/inf, i.v.) self-administration was carried out following three different protocols: 14 consecutive days of self-administration, 5 days/week for 3 weeks, with a 2-day interval between 5-day blocks of self-administration, and 3 days/week for 3 weeks, with a 4-day interval between 3-day blocks of self-administration. Daytime activity and activity-based sleep measures were evaluated with Actiwatch monitors a week before (baseline parameters) and throughout each protocol.

Results: Methamphetamine self-administration markedly disrupted sleep-like measures and increased daytime activity. Tolerance developed to those effects with repeated methamphetamine intake exceeding five consecutive days. Inclusion of washout periods (2 or 4 days) between blocks of methamphetamine self-administration attenuated the development of tolerance, with longer breaks from methamphetamine intake being more effective in maintaining the sleep-disrupting and stimulant effects of methamphetamine.

Conclusions: Tolerance can develop to the stimulant and sleep-disrupting effects of methamphetamine self-administration. Interruption of drug intake extends the effects of methamphetamine on sleep-like measures and daytime activity.

Citing Articles

Effects of methamphetamine on actigraphy-based sleep parameters in female rhesus monkeys: Orexin receptor mechanisms.

Borgatti D, Rowlett J, Berro L Drug Alcohol Depend. 2024; 259:111285.

PMID: 38636173 PMC: 11111337. DOI: 10.1016/j.drugalcdep.2024.111285.

Insomnia as a Risk Factor for Substance Use Disorders in Women.

Berro L Sleep Med Clin. 2024; 18(4):511-520.

PMID: 38501523 PMC: 10950003. DOI: 10.1016/j.jsmc.2023.06.010.

Methamphetamine-Induced Sleep Impairments and Subsequent Slow-Wave and Rapid Eye Movement Sleep Rebound in Male Rhesus Monkeys.

Berro L, Overton J, Rowlett J Front Neurosci. 2022; 16:866971.

PMID: 35464308 PMC: 9021839. DOI: 10.3389/fnins.2022.866971.

Influence of Pair-housing on Sleep Parameters Evaluated with Actigraphy in Female Rhesus Monkeys.

Berro L, Pareek T, Reeves-Darby J, Andersen M, Howell L, Platt D J Am Assoc Lab Anim Sci. 2022; 61(2):165-172.

PMID: 35012705 PMC: 8956211. DOI: 10.30802/AALAS-JAALAS-21-000027.

The dual orexin receptor antagonist almorexant blocks the sleep-disrupting and daytime stimulant effects of methamphetamine in rhesus monkeys.

Berro L, Moreira-Junior E, Rowlett J Drug Alcohol Depend. 2021; 227:108930.

PMID: 34358767 PMC: 8464508. DOI: 10.1016/j.drugalcdep.2021.108930.

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