Puzzling Out Synaptic Vesicle 2 Family Members Functions

Overview

Journal Front Mol Neurosci

Specialty Molecular Biology

Date 2017 Jun 8

PMID 28588450

Citations 54

Authors

Odile Bartholome

Priscilla Van Den Ackerveken

Judit Sanchez Gil

Orianne de la Brassinne Bonardeaux

Pierre Leprince

Rachelle Franzen

Bernard Rogister

Affiliations

Soon will be listed here.

Abstract

Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many functions have been suggested for SV2 proteins including ions or neurotransmitters transport or priming of SVs. Moreover, several recent studies highlighted the link between SV2 and different neuronal disorders such as epilepsy, Schizophrenia (SCZ), Alzheimer's or Parkinson's disease. In this review article, we will summarize our present knowledge on SV2A function(s) and its potential role(s) in the pathophysiology of various brain disorders.

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