Design, Synthesis, and Biological Activities of Novel Pyrazole Oxime Compounds Containing a Substituted Pyridyl Moiety

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2017 Jun 8

PMID 28587083

Authors

Cuili Chen

Jia Chen

Haiying Gu

Ning Bao

Hong Dai

Affiliations

Soon will be listed here.

Abstract

In this paper, in order to find novel biologically active pyrazole oximes, a series of pyrazole oxime compounds bearing a substituted pyridyl unit were prepared. Bioassays showed that some target compounds were found to have good acaricidal activity against at a concentration of 500 μg/mL, compound especially displayed potent acaricidal activity against when the concentration was reduced to 100 μg/mL. Interestingly, most target compounds possessed excellent insecticidal activities against at 500 μg/mL. Moreover, some compounds were active against and at 500 μg/mL. Additionally, compounds , , , , , , , , , and displayed significant antiproliferative activities against HepG2 cells with IC values of 1.53-17.27 μM, better than that of the control 5-fluorouracil (IC = 35.67 μM).

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