Models to Define the Stages of Articular Cartilage Degradation in Osteoarthritis Development

Overview

Journal Int J Exp Pathol

Publisher Wiley

Specialty Pathology

Date 2017 Jun 7

PMID 28585282

Citations 17

Authors

Blandine Poulet

Affiliations

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Abstract

Osteoarthritis (OA) is a common chronic disorder that affects an increasing number of the ageing population. Despite the prevalence, there are currently no therapies. Defining new therapies that target specific pathogenic phases of disease development relies on the effective separation of the different stages of OA. This manuscript reviews the tissues and models that are being used to separate these stages of disease, in particular initiation and early and late progression. These models include human tissues with known initiating factors, the use of anatomical locations with defined relationships to the primary cartilage lesion area, timing of OA development in well-described animal models and the versatility of a non-invasive model of murine knee joint trauma.

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References

Racunica T, Teichtahl A, Wang Y, Wluka A, English D, Giles G . Effect of physical activity on articular knee joint structures in community-based adults. Arthritis Rheum. 2007; 57(7):1261-8. DOI: 10.1002/art.22990. View

Wang T, Liang Y, Li H, Li H, He Q, Xue Y . Single Nucleotide Polymorphisms and Osteoarthritis: An Overview and a Meta-Analysis. Medicine (Baltimore). 2016; 95(7):e2811. PMC: 4998631. DOI: 10.1097/MD.0000000000002811. View

Kraus V, Blanco F, Englund M, Karsdal M, Lohmander L . Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use. Osteoarthritis Cartilage. 2015; 23(8):1233-41. PMC: 4516635. DOI: 10.1016/j.joca.2015.03.036. View

Burleigh A, Chanalaris A, Gardiner M, Driscoll C, Boruc O, Saklatvala J . Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo. Arthritis Rheum. 2012; 64(7):2278-88. DOI: 10.1002/art.34420. View

Tsezou A . Osteoarthritis year in review 2014: genetics and genomics. Osteoarthritis Cartilage. 2014; 22(12):2017-24. DOI: 10.1016/j.joca.2014.07.024. View

Cui Z, Xu C, Li X, Song J, Yu B . Treatment with recombinant lubricin attenuates osteoarthritis by positive feedback loop between articular cartilage and subchondral bone in ovariectomized rats. Bone. 2015; 74:37-47. DOI: 10.1016/j.bone.2014.12.065. View

Hildebrand B . Mutation in the type II collagen gene (COL2A1) as a cause of early osteoarthritis and juvenile idiopathic arthritis-A pseudorheumatoid arthritis variant. Semin Arthritis Rheum. 2015; 44(6):e22. DOI: 10.1016/j.semarthrit.2015.01.001. View

Gleghorn L, Ramesar R, Beighton P, Wallis G . A mutation in the variable repeat region of the aggrecan gene (AGC1) causes a form of spondyloepiphyseal dysplasia associated with severe, premature osteoarthritis. Am J Hum Genet. 2005; 77(3):484-90. PMC: 1226213. DOI: 10.1086/444401. View

Liu B, Goode A, Carter T, Utturkar G, Huebner J, Taylor D . Matrix metalloproteinase activity and prostaglandin E2 are elevated in the synovial fluid of meniscus tear patients. Connect Tissue Res. 2016; 58(3-4):305-316. PMC: 5418110. DOI: 10.1080/03008207.2016.1256391. View

10.

Reynard L . Analysis of genetics and DNA methylation in osteoarthritis: What have we learnt about the disease?. Semin Cell Dev Biol. 2016; 62:57-66. DOI: 10.1016/j.semcdb.2016.04.017. View

11.

Paassilta P, Lohiniva J, Annunen S, Bonaventure J, Le Merrer M, Pai L . COL9A3: A third locus for multiple epiphyseal dysplasia. Am J Hum Genet. 1999; 64(4):1036-44. PMC: 1377827. DOI: 10.1086/302328. View

12.

Rowe M, Harper L, McNulty M, Lau A, Carlson C, Leng L . Reduced Osteoarthritis Severity in Aged Mice With Deletion of Macrophage Migration Inhibitory Factor. Arthritis Rheumatol. 2016; 69(2):352-361. PMC: 5274570. DOI: 10.1002/art.39844. View

13.

Stahl R, Luke A, Li X, Carballido-Gamio J, Ma C, Majumdar S . T1rho, T2 and focal knee cartilage abnormalities in physically active and sedentary healthy subjects versus early OA patients--a 3.0-Tesla MRI study. Eur Radiol. 2008; 19(1):132-43. DOI: 10.1007/s00330-008-1107-6. View

14.

Valverde-Franco G, Pelletier J, Fahmi H, Hum D, Matsuo K, Lussier B . In vivo bone-specific EphB4 overexpression in mice protects both subchondral bone and cartilage during osteoarthritis. Arthritis Rheum. 2012; 64(11):3614-25. DOI: 10.1002/art.34638. View

15.

Jiang Y, Tuan R . Origin and function of cartilage stem/progenitor cells in osteoarthritis. Nat Rev Rheumatol. 2014; 11(4):206-12. PMC: 5413931. DOI: 10.1038/nrrheum.2014.200. View

16.

Struglics A, Larsson S, Kumahashi N, Frobell R, Lohmander L . Changes in Cytokines and Aggrecan ARGS Neoepitope in Synovial Fluid and Serum and in C-Terminal Crosslinking Telopeptide of Type II Collagen and N-Terminal Crosslinking Telopeptide of Type I Collagen in Urine Over Five Years After Anterior Cruciate.... Arthritis Rheumatol. 2015; 67(7):1816-25. DOI: 10.1002/art.39146. View

17.

Fukui N, Ikeda Y, Ohnuki T, Tanaka N, Hikita A, Mitomi H . Regional differences in chondrocyte metabolism in osteoarthritis: a detailed analysis by laser capture microdissection. Arthritis Rheum. 2008; 58(1):154-63. DOI: 10.1002/art.23175. View

18.

Little C, Barai A, Burkhardt D, Smith S, Fosang A, Werb Z . Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum. 2009; 60(12):3723-33. PMC: 2832925. DOI: 10.1002/art.25002. View

19.

Miller L, Sode M, Fuerst T, Block J . Joint unloading implant modifies subchondral bone trabecular structure in medial knee osteoarthritis: 2-year outcomes of a pilot study using fractal signature analysis. Clin Interv Aging. 2015; 10:351-7. PMC: 4315540. DOI: 10.2147/CIA.S76982. View

20.

Wang M, Sampson E, Jin H, Li J, Ke Q, Im H . MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Res Ther. 2013; 15(1):R5. PMC: 3672752. DOI: 10.1186/ar4133. View