On the Nature of Directed Behavior to Drug-associated Light Cues in Rhesus Monkeys ()

Overview

Journal Behav Anal (Wash D C)

Publisher American Psychological Association

Specialty Psychiatry

Date 2017 Jun 7

PMID 28584876

Authors

Mark P Reilly

Sonja I Berndt

James H Woods

Affiliations

Soon will be listed here.

Abstract

The present study investigated the role of drug-paired stimuli in controlling the behavior of rhesus monkeys. Systematic observations were made with nine monkeys who had a history of drug self-administration; they had been lever pressing to produce intravenous infusions of various drugs. These observations revealed that the stimulus light co-occurring with drug infusion produced robust and cue-directed behavior such as orienting, touching and biting. Experiment 1 showed that this light-directed behavior would occur in naïve monkeys exposed to a Pavlovian pairing procedure. Four monkeys were given response-independent injections of cocaine. In two monkeys, a red light preceded cocaine injections by 5 s, and a green light co-occurred with the 5-s cocaine injections. In the other two monkeys, the light presentations and cocaine injections occurred independently. Light-directed behavior occurred in all four monkeys within the first couple of trials and at high levels but decreased across sessions. The cocaine-paired stimulus maintained behavior longer and at higher levels than the uncorrelated stimuli. Furthermore, light-directed behavior was not maintained when cocaine was replaced with saline. Light-directed behavior did not occur in the absence of the lights. When these monkeys were subsequently trained to lever press for cocaine, light-directed behavior increased to levels higher than previously observed. Behavior directed towards drug-paired stimuli is robust, reliable and multiply determined; the mechanisms underlying this activity likely include Pavlovian conditioning, stimulus novelty, habituation and operant conditioning.

References

Locurto C, Travers T, Terrace H, Gibbon J . Physical restraint produces rapid acquisition of the pigeon's key peck. J Exp Anal Behav. 1980; 34(1):13-21. PMC: 1332941. DOI: 10.1901/jeab.1980.34-13. View

Gamzu E, Schwam E . Autoshaping and automaintenance of a key-press response in squirrel monkeys. J Exp Anal Behav. 1974; 21(2):361-71. PMC: 1333204. DOI: 10.1901/jeab.1974.21-361. View

Buzsaki G . The "where is it?" reflex: autoshaping the orienting response. J Exp Anal Behav. 1982; 37(3):461-84. PMC: 1333160. DOI: 10.1901/jeab.1982.37-461. View

Flagel S, Watson S, Akil H, Robinson T . Individual differences in the attribution of incentive salience to a reward-related cue: influence on cocaine sensitization. Behav Brain Res. 2007; 186(1):48-56. PMC: 2225480. DOI: 10.1016/j.bbr.2007.07.022. View

Brown P, Jenkins H . Auto-shaping of the pigeon's key-peck. J Exp Anal Behav. 1968; 11(1):1-8. PMC: 1338436. DOI: 10.1901/jeab.1968.11-1. View

Siegel S . Evidence from rats that morphine tolerance is a learned response. J Comp Physiol Psychol. 1975; 89(5):498-506. DOI: 10.1037/h0077058. View

Uslaner J, Acerbo M, Jones S, Robinson T . The attribution of incentive salience to a stimulus that signals an intravenous injection of cocaine. Behav Brain Res. 2006; 169(2):320-4. DOI: 10.1016/j.bbr.2006.02.001. View

Downing K, Neuringer A . Autoshaping as a function of prior food presentations. J Exp Anal Behav. 1976; 26(3):463-9. PMC: 1333536. DOI: 10.1901/jeab.1976.26-463. View

Peterson G, Ackilt J, Frommer G, Hearst E . Conditioned Approach and Contact Behavior toward Signals for Food or Brain-Stimulation Reinforcement. Science. 1972; 177(4053):1009-11. DOI: 10.1126/science.177.4053.1009. View

10.

BRIDGER W, Schiff S, Cooper S, PAREDES W, Barr G . Classical conditioning of cocaine's stimulatory effects. Psychopharmacol Bull. 1982; 18(4):210-4. View

11.

Jenkins H, Moore B . The form of the auto-shaped response with food or water reinforcers. J Exp Anal Behav. 1973; 20(2):163-81. PMC: 1334117. DOI: 10.1901/jeab.1973.20-163. View

12.

Sidman M, Fletcher F . A demonstration of auto-shaping with monkeys. J Exp Anal Behav. 1968; 11(3):307-9. PMC: 1338490. DOI: 10.1901/jeab.1968.11-307. View

13.

Davis W, Smith S . Role of conditioned reinforcers in the initiation, maintenance and extinction of drug-seeking behavior. Pavlov J Biol Sci. 1976; 11(4):222-36. DOI: 10.1007/BF03000316. View

14.

Shahan T . Stimuli produced by observing responses make rats' ethanol self-administration more resistant to price increases. Psychopharmacology (Berl). 2003; 167(2):180-6. DOI: 10.1007/s00213-003-1390-5. View

15.

Winger G, Palmer R, Woods J . Drug-reinforced responding: rapid determination of dose-response functions. Drug Alcohol Depend. 1989; 24(2):135-42. DOI: 10.1016/0376-8716(89)90076-8. View

16.

Gamzu E, Williams D . Associative factors underlying the pigeon's key pecking in auto-shaping procedures. J Exp Anal Behav. 1973; 19(2):225-32. PMC: 1334074. DOI: 10.1901/jeab.1973.19-225. View

17.

Flagel S, Akil H, Robinson T . Individual differences in the attribution of incentive salience to reward-related cues: Implications for addiction. Neuropharmacology. 2008; 56 Suppl 1:139-48. PMC: 2635343. DOI: 10.1016/j.neuropharm.2008.06.027. View

18.

Panlilio L, Schindler C . Conditioned locomotor-activating and reinforcing effects of discrete stimuli paired with intraperitoneal cocaine. Behav Pharmacol. 1998; 8(8):691-8. DOI: 10.1097/00008877-199712000-00003. View