Bone Metastases: An Overview

Overview

Journal Oncol Rev

Specialty Oncology

Date 2017 Jun 7

PMID 28584570

Citations 400

Authors

Filipa Macedo

Katia Ladeira

Filipa Pinho

Nadine Saraiva

Nuno Bonito

Luisa Pinto

Francisco Goncalves

Affiliations

Soon will be listed here.

Abstract

Bone is a frequent site of metastases and typically indicates a short-term prognosis in cancer patients. Once cancer has spread to the bones it can rarely be cured, but often it can still be treated to slow its growth. The majority of skeletal metastases are due to breast and prostate cancer. Bone metastasis is actually much more common than primary bone cancers, especially in adults. The diagnosis is based on signs, symptoms and imaging. New classes of drugs and new interventions are given a better quality of life to these patients and improved the expectancy of life. It is necessary a multidisciplinary approach to treat patients with bone metastasis. In this paper we review the types, clinical approach and treatment of bone metastases.

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References

Robinson R, PRESTON D, Baxter K, Dusing R, Spicer J . Clinical experience with strontium-89 in prostatic and breast cancer patients. Semin Oncol. 1993; 20(3 Suppl 2):44-8. View

Sohn S, Chung C . The role of stereotactic radiosurgery in metastasis to the spine. J Korean Neurosurg Soc. 2012; 51(1):1-7. PMC: 3291699. DOI: 10.3340/jkns.2012.51.1.1. View

Mazo I, von Andrian U . Adhesion and homing of blood-borne cells in bone marrow microvessels. J Leukoc Biol. 1999; 66(1):25-32. DOI: 10.1002/jlb.66.1.25. View

Body J, Coleman R, Piccart M . Use of bisphosphonates in cancer patients. Cancer Treat Rev. 1996; 22(4):265-87. DOI: 10.1016/s0305-7372(96)90020-1. View

Rosenthal D . Radiologic diagnosis of bone metastases. Cancer. 1997; 80(8 Suppl):1595-607. DOI: 10.1002/(sici)1097-0142(19971015)80:8+<1595::aid-cncr10>3.3.co;2-z. View

Rennert G, Pinchev M, Rennert H, Gruber S . Use of bisphosphonates and reduced risk of colorectal cancer. J Clin Oncol. 2011; 29(9):1146-50. PMC: 3083870. DOI: 10.1200/JCO.2010.33.7485. View

Guenther A, Gordon S, Tiemann M, Burger R, Bakker F, Green J . The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation. Int J Cancer. 2009; 126(1):239-46. DOI: 10.1002/ijc.24758. View

Callstrom M, Dupuy D, Solomon S, Beres R, Littrup P, Davis K . Percutaneous image-guided cryoablation of painful metastases involving bone: multicenter trial. Cancer. 2012; 119(5):1033-41. PMC: 5757505. DOI: 10.1002/cncr.27793. View

Kohno N, Kitazawa S, Fukase M, Sakoda Y, Kanbara Y, Furuya Y . The expression of parathyroid hormone-related protein in human breast cancer with skeletal metastases. Surg Today. 1994; 24(3):215-20. DOI: 10.1007/BF02032890. View

10.

Maisano R, Pergolizzi S, Cascinu S . Novel therapeutic approaches to cancer patients with bone metastasis. Crit Rev Oncol Hematol. 2001; 40(3):239-50. DOI: 10.1016/s1040-8428(01)00092-0. View

11.

Jhaveri P, Teh B, Bloch C, Amato R, Butler E, Paulino A . Stereotactic body radiotherapy in the management of painful bone metastases. Oncology (Williston Park). 2008; 22(7):782-8. View

12.

Clohisy D, Mantyh P . Bone cancer pain. Cancer. 2003; 97(3 Suppl):866-73. DOI: 10.1002/cncr.11144. View

13.

Saliken J, McKinnon J, Gray R . CT for monitoring cryotherapy. AJR Am J Roentgenol. 1996; 166(4):853-5. DOI: 10.2214/ajr.166.4.8610562. View

14.

Rennert G, Pinchev M, Rennert H . Use of bisphosphonates and risk of postmenopausal breast cancer. J Clin Oncol. 2010; 28(22):3577-81. DOI: 10.1200/JCO.2010.28.1113. View

15.

Southby J, Kissin M, Danks J, Hayman J, Moseley J, Henderson M . Immunohistochemical localization of parathyroid hormone-related protein in human breast cancer. Cancer Res. 1990; 50(23):7710-6. View

16.

Jones D, Nakashima T, Sanchez O, Kozieradzki I, Komarova S, Sarosi I . Regulation of cancer cell migration and bone metastasis by RANKL. Nature. 2006; 440(7084):692-6. DOI: 10.1038/nature04524. View

17.

Luzzi K, MacDonald I, Schmidt E, Kerkvliet N, Morris V, Chambers A . Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am J Pathol. 1998; 153(3):865-73. PMC: 1853000. DOI: 10.1016/S0002-9440(10)65628-3. View

18.

Iguchi K . [Effect of bisphosphonates on anticancer activity in prostate cancer cells]. Yakugaku Zasshi. 2012; 132(9):1025-30. DOI: 10.1248/yakushi.132.1025. View

19.

Coleman R, Seaman J . The role of zoledronic acid in cancer: clinical studies in the treatment and prevention of bone metastases. Semin Oncol. 2001; 28(2 Suppl 6):11-6. DOI: 10.1016/s0093-7754(01)90260-x. View

20.

Nielsen O, Munro A, Tannock I . Bone metastases: pathophysiology and management policy. J Clin Oncol. 1991; 9(3):509-24. DOI: 10.1200/JCO.1991.9.3.509. View