Schisandrae Fructus Reduces Symptoms of 4-Vinylcyclohexene Diepoxide-Induced Ovarian Failure in Mice

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2017 Jun 7

PMID 28584559

Citations 1

Authors

Dasom Shin

Jinhee Ha

Seong Bin Hong

Geun-Hyung Kang

Deok-Sang Hwang

Hyunsu Bae

Affiliations

Soon will be listed here.

Abstract

Menopause is associated with a decrease in the level of sex hormones such as ovarian estradiol and progesterone and can cause various symptoms such as depression, hot flash, fatigue, heart palpitations, and headache. Furthermore, there is a risk of developing complications such as osteoporosis, cardiovascular diseases, Alzheimer's disease, and ovarian cancer. Schisandrae Fructus (SF) is widely used in Korean medicine as a cure for such complications. This study was conducted to evaluate the therapeutic effects of SF against menopause symptoms associated with follicle depletion caused by the industrial chemical 4-vinylcyclohexene diepoxide (VCD) in mice. VCD directly targets the preantral follicles. Mice were injected with VCD (160 mg/kg intraperitoneally) daily for 15 days and then with SF dosage 3 times/week for six weeks. To evaluate the effects of SF, body weight, tail skin temperature, uterine weight, lipid profile, and osteocalcin levels were measured. A decrease in body weight and tail skin temperature and an increase in uterine weight were observed upon SF treatment. Moreover, SF treatment significantly decreased total cholesterol, triglyceride, osteocalcin, and low-density lipoprotein levels and low-density/high-density lipoprotein ratio. These results suggest the potential use of SF in the treatment of menopausal symptoms in women.

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References

Garner S, Anderson J, Mar M, Parikh I . Estrogens reduce bone loss in the ovariectomized, lactating rat model. Bone Miner. 1991; 15(1):19-31. DOI: 10.1016/0169-6009(91)90108-c. View

Chen P, Pang S, Yang N, Meng H, Liu J, Zhou N . Beneficial effects of schisandrin B on the cardiac function in mice model of myocardial infarction. PLoS One. 2013; 8(11):e79418. PMC: 3832629. DOI: 10.1371/journal.pone.0079418. View

Liu S, Tian L, Xu P, Zhuang G, Zheng F, Tian J . Analysis of correlation between blood biochemical indicators and bone mineral density of post-menopausal women. Mol Biol Rep. 2010; 38(2):939-48. DOI: 10.1007/s11033-010-0187-y. View

Acosta J, Mayer L, Talboom J, Tsang C, Smith C, Enders C . Transitional versus surgical menopause in a rodent model: etiology of ovarian hormone loss impacts memory and the acetylcholine system. Endocrinology. 2009; 150(9):4248-59. PMC: 2736080. DOI: 10.1210/en.2008-1802. View

Koebele S, Bimonte-Nelson H . Modeling menopause: The utility of rodents in translational behavioral endocrinology research. Maturitas. 2016; 87:5-17. PMC: 4829404. DOI: 10.1016/j.maturitas.2016.01.015. View

Kronenberg F . Menopausal hot flashes: a review of physiology and biosociocultural perspective on methods of assessment. J Nutr. 2010; 140(7):1380S-5S. DOI: 10.3945/jn.109.120840. View

Crespo C, Smit E, Snelling A, Sempos C, Andersen R . Hormone replacement therapy and its relationship to lipid and glucose metabolism in diabetic and nondiabetic postmenopausal women: results from the Third National Health and Nutrition Examination Survey (NHANES III). Diabetes Care. 2002; 25(10):1675-80. DOI: 10.2337/diacare.25.10.1675. View

Giridharan V, Thandavarayan R, Sato S, Ko K, Konishi T . Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice. Free Radic Res. 2011; 45(8):950-8. DOI: 10.3109/10715762.2011.571682. View

Nappi R, Sinforiani E, Mauri M, Bono G, Polatti F, Nappi G . Memory functioning at menopause: impact of age in ovariectomized women. Gynecol Obstet Invest. 1998; 47(1):29-36. DOI: 10.1159/000010058. View

10.

Wang X, Yu Z, Pan S, Zhang Y, Sun N, Zhu P . Supplementation with the extract of schisandrae fructus pulp, seed, or their combination influences the metabolism of lipids and glucose in mice fed with normal and hypercholesterolemic diet. Evid Based Complement Alternat Med. 2014; 2014:472638. PMC: 4021675. DOI: 10.1155/2014/472638. View

11.

Brooks H, Pollow D, Hoyer P . The VCD Mouse Model of Menopause and Perimenopause for the Study of Sex Differences in Cardiovascular Disease and the Metabolic Syndrome. Physiology (Bethesda). 2016; 31(4):250-7. PMC: 5504385. DOI: 10.1152/physiol.00057.2014. View

12.

Barrett-Connor E, Grady D . Hormone replacement therapy, heart disease, and other considerations. Annu Rev Public Health. 1998; 19:55-72. DOI: 10.1146/annurev.publhealth.19.1.55. View

13.

FINN C . Reproductive ageing and the menopause. Int J Dev Biol. 2001; 45(3):613-7. View

14.

Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B . Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA. 1998; 280(7):605-13. DOI: 10.1001/jama.280.7.605. View

15.

Ko K, Ip S, Poon M, Wu S, Che C, Ng K . Effect of a lignan-enriched fructus schisandrae extract on hepatic glutathione status in rats: protection against carbon tetrachloride toxicity. Planta Med. 1995; 61(2):134-7. DOI: 10.1055/s-2006-958032. View

16.

Zhang Y, Wang L, Zhang D, Zhou L, Guo Y . Ultrasound-assisted extraction and purification of schisandrin B from Schisandra chinensis (Turcz.) Baill seeds: optimization by response surface methodology. Ultrason Sonochem. 2013; 21(2):461-6. DOI: 10.1016/j.ultsonch.2013.09.009. View

17.

Jang M, Yun Y, Kim S, Kim J, Jung M . Protective Effect of Gomisin N against Endoplasmic Reticulum Stress-Induced Hepatic Steatosis. Biol Pharm Bull. 2016; 39(5):832-8. DOI: 10.1248/bpb.b15-01020. View

18.

Appt S, Ethun K . Reproductive aging and risk for chronic disease: Insights from studies of nonhuman primates. Maturitas. 2010; 67(1):7-14. PMC: 2941880. DOI: 10.1016/j.maturitas.2010.03.028. View

19.

Fan X, Duan X, Chen Z, Li M, Xu J, Ding G . Lack of estrogen down-regulates CXCR4 expression on Treg cells and reduces Treg cell population in bone marrow in OVX mice. Cell Mol Biol (Noisy-le-grand). 2015; 61(2):13-7. View

20.

Del Pino J, Cordero M, Lanchares J, Garcia-Talavera J . Influence of sex, age, and menopause in serum osteocalcin (BGP) levels. Klin Wochenschr. 1990; 69(24):1135-8. DOI: 10.1007/BF01815430. View