Chemical Composition and Hypotensive Effect of

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2017 Jun 7

PMID 28584558

Citations 7

Authors

Liane Santariano SantAnna

Liara Merlugo

Catrine Santos Ehle

Jessica Limberger

Maquelen Blanco Fernandes

Mari Castro Santos

Andreas Sebastian Loureiro Mendez

Favero Reisdorfer Paula

Cleci Menezes Moreira

Affiliations

Soon will be listed here.

Abstract

is known in Brazil as Guabiroba and is popularly used for various diseases, such as inflammatory, renal, and digestive diseases and dyslipidemia. The aim of the study was to analyze the chemical composition and investigate the effects of aqueous extract of on the blood pressure of normotensive rats, analyzing the possible action mechanism using experimental and in silico procedures. The extract was evaluated for total phenolic compounds and total flavonoid content. The chemical components were determined by HPLC analyses. Systolic and diastolic blood pressure and heart rate were measured with extract and drugs administration. The leaves of presented the relevant content of phenolics and flavonoids, and we suggested the presence of chlorogenic acid, gallic acid, quercetin, and theobromine. The acute administration of aqueous extract of has a dose-dependent hypotensive effect in normotensive rats, suggesting that the action mechanism may be mediated through the renin-angiotensin system by AT1 receptor blockade and sympathetic autonomic response. Docking studies showed models that indicated an interaction between chlorogenic acid and quercetin with the AT1 receptor (AT1R) active site. The findings of these docking studies suggest the potential of constituents for use as preventive agents for blood pressure.

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