Therapeutic Angiogenesis of Adipose-derived Stem Cells for Ischemic Diseases

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2017 Jun 7

PMID 28583178

Citations 90

Authors

Lina Zhao

Takerra Johnson

Dong Liu

Affiliations

Soon will be listed here.

Abstract

Ischemic diseases, the leading cause of disability and death, are caused by the stenosis or obstruction of arterioles/capillaries that is not compensated for by vessel dilatation or collateral circulation. Angiogenesis is a complex process leading to new blood vessel formation and is triggered by ischemic conditions. Adequate angiogenesis, as a compensatory mechanism in response to ischemia, may increase oxygen and nutrient supplies to tissues and protect their function. Therapeutic angiogenesis has been the most promising therapy for treating ischemic diseases. In recent years, stem cell transplantation has been recognized as a new technique with therapeutic angiogenic effects on ischemic diseases. Adipose-derived stem cells, characterized by their ease of acquisition, high yields, proliferative growth, and low immunogenicity, are an ideal cell source. In this review, the characterization of adipose-derived stem cells and the role of angiogenesis in ischemic attack are summarized. The angiogenic effects of adipose-derived stem cells are discussed from the perspectives of in-vitro, in-vivo, and clinical trial studies for the treatment of ischemic diseases, including ischemic cardiac, cerebral, and peripheral vascular diseases and wound healing. The microvesicles/exosomes released from adipose-derived stem cells are also presented as a novel therapeutic prospect for treating ischemic diseases.

Citing Articles

Therapeutic Potential of Adipose-Derived Regenerative Cells for Ischemic Diseases.

Che Y, Shimizu Y, Murohara T Cells. 2025; 14(5).

PMID: 40072072 PMC: 11898683. DOI: 10.3390/cells14050343.

Enhanced human adipose-derived stem cells with VEGFA and bFGF mRNA promote stable vascular regeneration and improve cardiac function following myocardial infarction.

Li K, Luo R, Yu X, Dong W, Hao G, Hu D Clin Transl Med. 2025; 15(3):e70250.

PMID: 40008489 PMC: 11862888. DOI: 10.1002/ctm2.70250.

Exosomes derived from minor salivary gland mesenchymal stem cells: a promising novel exosome exhibiting pro-angiogenic and wound healing effects similar to those of adipose-derived stem cell exosomes.

Xiang H, Ding P, Qian J, Lu E, Sun Y, Lee S Stem Cell Res Ther. 2024; 15(1):462.

PMID: 39627883 PMC: 11616330. DOI: 10.1186/s13287-024-04069-5.

Extracellular vesicles from human adipose-derived stem cell spheroids: Characterization and therapeutic implications in diabetic wound healing.

Quinones E, Wang M, Liu K, Lu T, Lan G, Lin Y Mater Today Bio. 2024; 29:101333.

PMID: 39619638 PMC: 11605404. DOI: 10.1016/j.mtbio.2024.101333.

The Effects of Mesenchymal Stem Cells-Derived Exosomes on Metabolic Reprogramming in Scar Formation and Wound Healing.

Gong X, Zhao Q, Zhang H, Liu R, Wu J, Zhang N Int J Nanomedicine. 2024; 19:9871-9887.

PMID: 39345908 PMC: 11438468. DOI: 10.2147/IJN.S480901.

References

Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove C, Bovenkerk J . Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation. 2004; 109(10):1292-8. DOI: 10.1161/01.CIR.0000121425.42966.F1. View

Xu Y, Shi T, Xu A, Zhang L . 3D spheroid culture enhances survival and therapeutic capacities of MSCs injected into ischemic kidney. J Cell Mol Med. 2016; 20(7):1203-13. PMC: 4929304. DOI: 10.1111/jcmm.12651. View

Cai L, Johnstone B, Cook T, Tan J, Fishbein M, Chen P . IFATS collection: Human adipose tissue-derived stem cells induce angiogenesis and nerve sprouting following myocardial infarction, in conjunction with potent preservation of cardiac function. Stem Cells. 2008; 27(1):230-7. PMC: 2936459. DOI: 10.1634/stemcells.2008-0273. View

Borlongan C . Age of PISCES: stem-cell clinical trials in stroke. Lancet. 2016; 388(10046):736-8. DOI: 10.1016/S0140-6736(16)31259-4. View

Haycock J . 3D cell culture: a review of current approaches and techniques. Methods Mol Biol. 2010; 695:1-15. DOI: 10.1007/978-1-60761-984-0_1. View

Ebrahimian T, Pouzoulet F, Squiban C, Buard V, Andre M, Cousin B . Cell therapy based on adipose tissue-derived stromal cells promotes physiological and pathological wound healing. Arterioscler Thromb Vasc Biol. 2009; 29(4):503-10. DOI: 10.1161/ATVBAHA.108.178962. View

Henry T, Annex B, McKendall G, Azrin M, Lopez J, Giordano F . The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis. Circulation. 2003; 107(10):1359-65. DOI: 10.1161/01.cir.0000061911.47710.8a. View

Wang L, Deng J, Tian W, Xiang B, Yang T, Li G . Adipose-derived stem cells are an effective cell candidate for treatment of heart failure: an MR imaging study of rat hearts. Am J Physiol Heart Circ Physiol. 2009; 297(3):H1020-31. DOI: 10.1152/ajpheart.01082.2008. View

Zografou A, Papadopoulos O, Tsigris C, Kavantzas N, Michalopoulos E, Chatzistamatiou T . Autologous transplantation of adipose-derived stem cells enhances skin graft survival and wound healing in diabetic rats. Ann Plast Surg. 2013; 71(2):225-32. DOI: 10.1097/SAP.0b013e31826af01a. View

10.

Atluri P, Woo Y . Pro-angiogenic cytokines as cardiovascular therapeutics: assessing the potential. BioDrugs. 2008; 22(4):209-22. DOI: 10.2165/00063030-200822040-00001. View

11.

Berardi G, Rebelatto C, Tavares H, Ingberman M, Shigunov P, Barchiki F . Transplantation of SNAP-treated adipose tissue-derived stem cells improves cardiac function and induces neovascularization after myocardium infarct in rats. Exp Mol Pathol. 2010; 90(2):149-56. DOI: 10.1016/j.yexmp.2010.11.005. View

12.

Gutierrez-Fernandez M, Rodriguez-Frutos B, Ramos-Cejudo J, Otero-Ortega L, Fuentes B, Vallejo-Cremades M . Comparison between xenogeneic and allogeneic adipose mesenchymal stem cells in the treatment of acute cerebral infarct: proof of concept in rats. J Transl Med. 2015; 13:46. PMC: 4322805. DOI: 10.1186/s12967-015-0406-3. View

13.

Kang T, Jones T, Naddell C, Bacanamwo M, Calvert J, Thompson W . Adipose-Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA-31. Stem Cells Transl Med. 2016; 5(4):440-50. PMC: 4798737. DOI: 10.5966/sctm.2015-0177. View

14.

Haney M, Klyachko N, Zhao Y, Gupta R, Plotnikova E, He Z . Exosomes as drug delivery vehicles for Parkinson's disease therapy. J Control Release. 2015; 207:18-30. PMC: 4430381. DOI: 10.1016/j.jconrel.2015.03.033. View

15.

Nie C, Zhang G, Yang D, Liu T, Liu D, Xu J . Targeted delivery of adipose-derived stem cells via acellular dermal matrix enhances wound repair in diabetic rats. J Tissue Eng Regen Med. 2012; 9(3):224-35. DOI: 10.1002/term.1622. View

16.

Mitchell J, McIntosh K, Zvonic S, Garrett S, Floyd Z, Kloster A . Immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markers. Stem Cells. 2005; 24(2):376-85. DOI: 10.1634/stemcells.2005-0234. View

17.

Yoo J, Shin J, An M, Ha T, Kim K, Bae K . Adipose-tissue-derived Stem Cells Enhance the Healing of Ischemic Colonic Anastomoses: An Experimental Study in Rats. J Korean Soc Coloproctol. 2012; 28(3):132-9. PMC: 3398108. DOI: 10.3393/jksc.2012.28.3.132. View

18.

Shevchenko E, Makarevich P, Tsokolaeva Z, Boldyreva M, Sysoeva V, Tkachuk V . Transplantation of modified human adipose derived stromal cells expressing VEGF165 results in more efficient angiogenic response in ischemic skeletal muscle. J Transl Med. 2013; 11:138. PMC: 3680170. DOI: 10.1186/1479-5876-11-138. View

19.

Madonna R, De Caterina R . In vitro neovasculogenic potential of resident adipose tissue precursors. Am J Physiol Cell Physiol. 2008; 295(5):C1271-80. DOI: 10.1152/ajpcell.00186.2008. View

20.

De Ugarte D, Morizono K, Elbarbary A, Alfonso Z, ZuK P, Zhu M . Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs. 2003; 174(3):101-9. DOI: 10.1159/000071150. View