Advances on the Transfer of Lipids by Lipid Transfer Proteins

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 2017 Jun 6

PMID 28579073

Citations 87

Authors

Louise H Wong

Alenka copic

Tim P Levine

Affiliations

Soon will be listed here.

Abstract

Transfer of lipid across the cytoplasm is an essential process for intracellular lipid traffic. Lipid transfer proteins (LTPs) are defined by highly controlled in vitro experiments. The functional relevance of these is supported by evidence for the same reactions inside cells. Major advances in the LTP field have come from structural bioinformatics identifying new LTPs, and from the development of countercurrent models for LTPs. However, the ultimate aim is to unite in vitro and in vivo data, and this is where much progress remains to be made. Even where in vitro and in vivo experiments align, rates of transfer tend not to match. Here we set out some of the advances that might test how LTPs work.

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