Mathermycin, a Lantibiotic from the Marine Actinomycete Marinactinospora Thermotolerans SCSIO 00652

Overview

Journal Appl Environ Microbiol

Specialties Environmental Health
Microbiology

Date 2017 Jun 4

PMID 28576760

Citations 17

Authors

Erquan Chen

Qi Chen

Shaoming Chen

Bing Xu

Jianhua Ju

Huan Wang

Affiliations

Soon will be listed here.

Abstract

Lantibiotics are antimicrobial peptides belonging to the family of ribosomally synthesized and posttranslationally modified peptides (RiPPs) and feature thioether linkages in their structures. In this study, we identified the biosynthetic gene cluster of a cinnamycin analog, named mathermycin, from SCSIO 00652 and reconstituted its biosynthesis in and Key posttranslational modification enzymes of mathermycin were characterized. Mathermycin exhibited antimicrobial activity and therefore represents an example of cinnamycin-like lantibiotics from species. The discovery of new antimicrobial compounds that can be used as potential drugs is in urgent need due to increasing bacterial resistance to current antibiotics. Lantibiotics are important antimicrobial compounds that have found applications in both the clinic setting and food industry. We report here the discovery of a new lantibiotic, mathermycin, from a marine-derived strain and elucidation of its biosynthesis. We also demonstrate that mathermycin possesses antimicrobial activity toward a strain.

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