Effects of Infant Weight Gain on Subsequent Allergic Outcomes in the First 3 years of Life

Overview

Journal BMC Pediatr

Publisher Biomed Central

Specialty Pediatrics

Date 2017 Jun 4

PMID 28576134

Citations 2

Authors

Evelyn Xiu-Ling Loo

Anne Goh

Izzuddin Bin Mohd Aris

Oon Hoe Teoh

Lynette Pei-Chi Shek

Bee Wah Lee

Yiong Huak Chan

Mya Thway Tint

Shu-E Soh

Seang-Mei Saw

Peter Gluckman

Keith M Godfrey

Yap-Seng Chong

Fabian Yap

Michael S Kramer

Hugo van Bever

Yung Seng Lee

Affiliations

Soon will be listed here.

Abstract

Background: The association between early weight gain and later allergic outcomes has not been well studied. We examined the relation between weight gain and the subsequent development of allergic outcomes in the first 36 months of life in a Singapore birth cohort.

Methods: In repeated visits in the first 15 months, we measured infant weight and administered questionnaires ascertaining allergic outcomes. At ages 18 and 36 months, we administered skin prick tests (SPTs) to inhalant and food allergens.

Results: At 18 months, 13.5% had a positive SPT, 3.5% had wheeze and a positive SPT, 3.9% had rhinitis and a positive SPT, and 6.1% had eczema and a positive SPT. Higher weight gain from 6 to 9 months, 9 to 12 months and 12 to 15 months were independently associated with a reduced risk of developing a positive SPT at 18 months (p-trend ≤0.03). At 36 months, 23.5% had a positive SPT, 11.9% had wheeze and a positive SPT, 12.2% rhinitis and a positive SPT, and 11.5% eczema and a positive SPT. Higher weight gain from 12 to 15 months was associated with a reduced risk of developing a positive SPT at 36 months (p-trend <0.01). No significant associations were observed between weight gain in any period and wheeze, rhinitis or eczema combined with a positive SPT at 18 or 36 months.

Conclusion: Higher weight gain in the first 15 months of life was associated with a reduced risk of allergen sensitization, but not with combinations of allergic symptoms.

Trial Registration: NCT01174875 Registered 1 July 2010, retrospectively registered.

Citing Articles

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The effect of catch-up growth in the first year of life on later wheezing phenotypes.

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