GENO PROTECTIVE AND ANTI-APOPTOTIC EFFECT OF GREEN TEA AGAINST PERINATAL LIPOPOLYSACCHARIDE-EXPOSURE INDUCED LIVER TOXICITY IN RAT NEWBORNS

Overview

Journal Afr J Tradit Complement Altern Med

Specialty Rehabilitation Medicine

Date 2017 Jun 3

PMID 28573233

Citations 3

Authors

Ahmed A Allam

Sami A Gabr

Jamaan Ajarem

Ahmad H Alghadir

Revathi Sekar

Billy Kc Chow

Affiliations

Soon will be listed here.

Abstract

Background: This study aims to examine the protective effect of green tea on the disturbances in oxidative stress and apoptosis related factors, mostly produced due to perinatal lipopolysaccharide (LPS) exposure, that subsequently induces liver cell damage.

Materials And Methods: Anti-free radical, Antioxidant, scavenging, geno-protective, and antiapoptotic activity of aqueous green tea extract (AGTE) were assessed against LPS-induced hepatic dysfunction in newborn-rats. AGTE at doses of 100 & 200 mg/kg was orally administered daily to rat dams, during gestation and lactation.

Results: AGTE was observed to exhibit protective effects by significantly attenuating LPS-induced alterations in serum AST, ALT, bilirubin, and albumin levels. Significant increase in the total antioxidant capacity (TAC), DNA contents, and reduction in nitric oxide (NO) levels were observed in AGTE treated rats comparing LPS-toxicated ones. Additionally, AGTE treatment significantly down-regulated apoptotic markers and this effect was directly correlated to the degree of hepatic fibrosis. The possible mechanisms of the potential therapeutic-liver protective effect of AGTE could be due to free radical scavenging potential and antiapoptotic properties caused by the presence of antioxidant polyphenolic components in AGTE.

Conclusion: We thereby propose, based on our findings, that the anti-free radical and anti-apoptotic inducing properties of AGTE active constituents attribute to its functional efficacy as anti-fibrotic agent.

Citing Articles

Protective Effects of Green Tea Supplementation against Lead-Induced Neurotoxicity in Mice.

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Anti-Apoptotic Role of Sanhuang Xiexin Decoction and Anisodamine in Endotoxemia.

Liu Z, Wang W, Luo J, Zhang Y, Zhang Y, Gan Z Front Pharmacol. 2021; 12:531325.

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Neurobehavioral changes in mice offspring exposed to green tea during fetal and early postnatal development.

Ajarem J, Rashedi G, Mohany M, Allam A Behav Brain Funct. 2017; 13(1):10.

PMID: 28569203 PMC: 5452299. DOI: 10.1186/s12993-017-0128-1.

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