Understanding Long-term Silver Release from Surface Modified Porous Titanium Implants

Overview

Journal Acta Biomater

Publisher Elsevier

Specialty Biomedical Engineering

Date 2017 Jun 3

PMID 28571692

Citations 16

Authors

Anish Shivaram

Susmita Bose

Amit Bandyopadhyay

Affiliations

Soon will be listed here.

Abstract

Statement Of Significance: Prevention of orthopedic device related infection using antibiotics has met with limited success and is still a big concern during post-surgery. Use of silver as an antibiotic treatment to prevent surgical infections is being explored due to the well-established antimicrobial properties of silver. However, in most cases silver is used in particulate form with wound dressings or with short-term devices such as catheters but not with load-bearing implants. We hypothesize that strongly adherent silver to load-bearing implants can offer longer-term solution towards infection in vivo. Keeping that in mind, the focus of this study was to understand the long-term release of silver ions, for a period of minimum 6months, from silver coated surface modified porous titanium implants.

Citing Articles

Prevention of Implant-Associated Infections Caused by Antibiotic-Resistant Bacteria through Biofunctionalization of Additively Manufactured Porous Titanium.

van Hengel I, Dijk B, Modaresifar K, Hooning van Duyvenbode J, Nurmohamed F, Leeflang M J Funct Biomater. 2023; 14(10).

PMID: 37888185 PMC: 10607138. DOI: 10.3390/jfb14100520.

Long-term changes in serum silver concentrations after extremity reconstruction with silver-coated megaprostheses.

Smolle M, Bergovec M, Scheipl S, Gossler W, Amerstorfer F, Glehr M Sci Rep. 2022; 12(1):13041.

PMID: 35906279 PMC: 9338280. DOI: 10.1038/s41598-022-16707-0.

Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges.

Cao H, Qiao S, Qin H, Jandt K J Funct Biomater. 2022; 13(3).

PMID: 35893454 PMC: 9326756. DOI: 10.3390/jfb13030086.

The preparation of a difunctional porous β-tricalcium phosphate scaffold with excellent compressive strength and antibacterial properties.

Qin L, Yi J, Xuefei L, Li L, Kenan X, Lu X RSC Adv. 2022; 10(47):28397-28407.

PMID: 35519120 PMC: 9055648. DOI: 10.1039/d0ra02388d.

Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization.

Sheng X, Wang A, Wang Z, Liu H, Wang J, Li C Front Bioeng Biotechnol. 2022; 10:850110.

PMID: 35299643 PMC: 8921557. DOI: 10.3389/fbioe.2022.850110.

References

Jones J, Ehrenfried L, Saravanapavan P, Hench L . Controlling ion release from bioactive glass foam scaffolds with antibacterial properties. J Mater Sci Mater Med. 2006; 17(11):989-96. DOI: 10.1007/s10856-006-0434-x. View

Kim J, Kuk E, Yu K, Kim J, Park S, Lee H . Antimicrobial effects of silver nanoparticles. Nanomedicine. 2007; 3(1):95-101. DOI: 10.1016/j.nano.2006.12.001. View

Pollini M, Paladini F, Catalano M, Taurino A, Licciulli A, Maffezzoli A . Antibacterial coatings on haemodialysis catheters by photochemical deposition of silver nanoparticles. J Mater Sci Mater Med. 2011; 22(9):2005-12. DOI: 10.1007/s10856-011-4380-x. View

Nandi S, Shivaram A, Bose S, Bandyopadhyay A . Silver nanoparticle deposited implants to treat osteomyelitis. J Biomed Mater Res B Appl Biomater. 2017; 106(3):1073-1083. PMC: 5685947. DOI: 10.1002/jbm.b.33910. View

Das K, Bose S, Bandyopadhyay A . Surface modifications and cell-materials interactions with anodized Ti. Acta Biomater. 2007; 3(4):573-85. DOI: 10.1016/j.actbio.2006.12.003. View

Chen W, Liu Y, Courtney H, Bettenga M, Agrawal C, Bumgardner J . In vitro anti-bacterial and biological properties of magnetron co-sputtered silver-containing hydroxyapatite coating. Biomaterials. 2006; 27(32):5512-7. DOI: 10.1016/j.biomaterials.2006.07.003. View

Alexander J . History of the medical use of silver. Surg Infect (Larchmt). 2009; 10(3):289-92. DOI: 10.1089/sur.2008.9941. View

Alt V, Bechert T, Steinrucke P, Wagener M, Seidel P, Dingeldein E . An in vitro assessment of the antibacterial properties and cytotoxicity of nanoparticulate silver bone cement. Biomaterials. 2004; 25(18):4383-91. DOI: 10.1016/j.biomaterials.2003.10.078. View

Haas D, McAndrew M . Bacterial osteomyelitis in adults: evolving considerations in diagnosis and treatment. Am J Med. 1996; 101(5):550-61. DOI: 10.1016/s0002-9343(96)00260-4. View

10.

Devasconcellos P, Bose S, Beyenal H, Bandyopadhyay A, Zirkle L . Antimicrobial Particulate Silver Coatings on Stainless Steel Implants for Fracture Management. Mater Sci Eng C Mater Biol Appl. 2012; 32(5):1112-1120. PMC: 3375829. DOI: 10.1016/j.msec.2012.02.020. View

11.

Bosetti M, Masse A, Tobin E, Cannas M . Silver coated materials for external fixation devices: in vitro biocompatibility and genotoxicity. Biomaterials. 2002; 23(3):887-92. DOI: 10.1016/s0142-9612(01)00198-3. View

12.

Mah T, OToole G . Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol. 2001; 9(1):34-9. DOI: 10.1016/s0966-842x(00)01913-2. View

13.

Monteiro D, Gorup L, Takamiya A, Ruvollo-Filho A, de Camargo E, Barbosa D . The growing importance of materials that prevent microbial adhesion: antimicrobial effect of medical devices containing silver. Int J Antimicrob Agents. 2009; 34(2):103-10. DOI: 10.1016/j.ijantimicag.2009.01.017. View

14.

Molleman B, Hiemstra T . Surface Structure of Silver Nanoparticles as a Model for Understanding the Oxidative Dissolution of Silver Ions. Langmuir. 2015; 31(49):13361-72. DOI: 10.1021/acs.langmuir.5b03686. View

15.

Mei S, Wang H, Wang W, Tong L, Pan H, Ruan C . Antibacterial effects and biocompatibility of titanium surfaces with graded silver incorporation in titania nanotubes. Biomaterials. 2014; 35(14):4255-65. DOI: 10.1016/j.biomaterials.2014.02.005. View

16.

Zhao L, Chu P, Zhang Y, Wu Z . Antibacterial coatings on titanium implants. J Biomed Mater Res B Appl Biomater. 2009; 91(1):470-80. DOI: 10.1002/jbm.b.31463. View

17.

Tsaras G, Osmon D, Mabry T, Lahr B, St Sauveur J, Yawn B . Incidence, secular trends, and outcomes of prosthetic joint infection: a population-based study, olmsted county, Minnesota, 1969-2007. Infect Control Hosp Epidemiol. 2012; 33(12):1207-12. PMC: 3602045. DOI: 10.1086/668421. View

18.

Eby D, Luckarift H, Johnson G . Hybrid antimicrobial enzyme and silver nanoparticle coatings for medical instruments. ACS Appl Mater Interfaces. 2010; 1(7):1553-60. DOI: 10.1021/am9002155. View

19.

Hoover S, Tarafder S, Bandyopadhyay A, Bose S . Silver doped resorbable tricalcium phosphate scaffolds for bone graft applications. Mater Sci Eng C Mater Biol Appl. 2017; 79:763-769. PMC: 5609511. DOI: 10.1016/j.msec.2017.04.132. View

20.

Hardes J, Ahrens H, Gebert C, Streitbuerger A, Buerger H, Erren M . Lack of toxicological side-effects in silver-coated megaprostheses in humans. Biomaterials. 2007; 28(18):2869-75. DOI: 10.1016/j.biomaterials.2007.02.033. View