Differences in Molecular Regulation Between Osteochondroma and Bizarre Parosteal Osteochondromatous Proliferation

Overview

Journal Mol Med Rep

Specialty Molecular Biology

Date 2017 Jun 1

PMID 28560436

Citations 1

Authors

Xinrong Zhou

Lihui Deng

Xinsheng Han

Yi Chen

Jiao Wang

Shengnan Du

Affiliations

Soon will be listed here.

Abstract

The differences in molecular mechanisms between osteochondroma and bizarre parosteal osteochondromatous proliferation (BPOP) remain to be fully elucidated. In the present study, the differentially expressed genes between BPOP and osteochondroma were obtained from the Gene Expression Omnibus online database, and the associations among these genes were analyzed using the Database for Annotation, Visualization, and Integrated Discovery (DAVID) online bioinformatics software. The results revealed several differentially expressed genes between human BPOP and osteochondroma. These differentially expressed genes were also enriched in different subgroups based on the analysis using DAVID online software, including 'transforming growth factor β receptor signaling pathway', 'BMP signaling pathway', 'Wnt receptor signaling pathway', 'response to chemical stimulus', 'regulation of inflammatory response', 'response to stress', 'glycosaminoglycan binding', 'polysaccharide binding', 'extracellular matrix structural constituent' and 'growth factors binding'. Taken together, these findings led to the conclusion that different gene regulatory mechanisms exist between BPOP and osteochondroma. Environmental stimulation and inflammation may contribute to BPOP or osteochondroma, and differences in extracellular matrix may contribute to differences in biological characteristics between BPOP and osteochondroma.

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References

Abramovici L, Steiner G . Bizarre parosteal osteochondromatous proliferation (Nora's lesion): a retrospective study of 12 cases, 2 arising in long bones. Hum Pathol. 2003; 33(12):1205-10. DOI: 10.1053/hupa.2002.130103. View

Kim S, Myoung H, Lee S, Kim Y, Lee S . Bizarre parosteal osteochondromatous proliferation in the lingual area of the mandibular body versus osteochondroma at the mandibular condyle. World J Surg Oncol. 2016; 14(1):35. PMC: 4750297. DOI: 10.1186/s12957-016-0777-9. View

Torreggiani W, Munk P, Al-Ismail K, OConnell J, Nicolaou S, Lee M . MR imaging features of bizarre parosteal osteochondromatous proliferation of bone (Nora's lesion). Eur J Radiol. 2001; 40(3):224-31. DOI: 10.1016/s0720-048x(01)00362-x. View

Panagopoulos I, Bjerkehagen B, Gorunova L, Taksdal I, Heim S . Rearrangement of chromosome bands 12q14~15 causing HMGA2-SOX5 gene fusion and HMGA2 expression in extraskeletal osteochondroma. Oncol Rep. 2015; 34(2):577-84. PMC: 4487666. DOI: 10.3892/or.2015.4035. View

Roychoudhury A, Bhatt K, Yadav R, Bhutia O, Roychoudhury S . Review of osteochondroma of mandibular condyle and report of a case series. J Oral Maxillofac Surg. 2011; 69(11):2815-23. DOI: 10.1016/j.joms.2010.10.016. View

Tanteles G, Nicolaou M, Neocleous V, Shammas C, Loizidou M, Alexandrou A . Genetic screening of EXT1 and EXT2 in Cypriot families with hereditary multiple osteochondromas. J Genet. 2015; 94(4):749-54. DOI: 10.1007/s12041-015-0564-3. View

Clough E, Barrett T . The Gene Expression Omnibus Database. Methods Mol Biol. 2016; 1418:93-110. PMC: 4944384. DOI: 10.1007/978-1-4939-3578-9_5. View

Kumar A, Khan S, Kumar V, Sharma M . Bizarre parosteal osteochondromatous proliferation (Nora's lesion) of phalanx in a child. BMJ Case Rep. 2014; 2014. PMC: 3902343. DOI: 10.1136/bcr-2013-201714. View

Huang D, Sherman B, Tan Q, Kir J, Liu D, Bryant D . DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists. Nucleic Acids Res. 2007; 35(Web Server issue):W169-75. PMC: 1933169. DOI: 10.1093/nar/gkm415. View

10.

Nilsson M, Domanski H, Mertens F, Mandahl N . Molecular cytogenetic characterization of recurrent translocation breakpoints in bizarre parosteal osteochondromatous proliferation (Nora's lesion). Hum Pathol. 2004; 35(9):1063-9. DOI: 10.1016/j.humpath.2004.02.008. View

11.

Sakamoto A, Imamura S, Matsumoto Y, Harimaya K, Matsuda S, Takahashi Y . Bizarre parosteal osteochondromatous proliferation with an inversion of chromosome 7. Skeletal Radiol. 2011; 40(11):1487-90. DOI: 10.1007/s00256-011-1173-8. View

12.

Huang D, Sherman B, Lempicki R . Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009; 4(1):44-57. DOI: 10.1038/nprot.2008.211. View

13.

Ting B, Jupiter J . Recurrent bizarre parosteal osteochondromatous proliferation of the ulna with erosion of the adjacent radius: case report. J Hand Surg Am. 2013; 38(12):2381-6. DOI: 10.1016/j.jhsa.2013.09.024. View

14.

Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis N . Osteochondromas: review of the clinical, radiological and pathological features. In Vivo. 2008; 22(5):633-46. View

15.

Sarrion P, Sangorrin A, Urreizti R, Delgado A, Artuch R, Martorell L . Mutations in the EXT1 and EXT2 genes in Spanish patients with multiple osteochondromas. Sci Rep. 2013; 3:1346. PMC: 3581825. DOI: 10.1038/srep01346. View