Urinary Arsenic Speciation in Children and Pregnant Women from Spain

Overview

Journal Expo Health

Specialty Environmental Health

Date 2017 May 30

PMID 28553665

Citations 13

Authors

Antonio J Signes-Pastor

Manus Carey

Jesus Vioque

Eva M Navarrete-Munoz

Cristina Rodriguez-Dehli

Adonina Tardon

Miren Begona-Zubero

Loreto Santa-Marina

Martine Vrijheid

Maribel Casas

Sabrina Llop

Sandra Gonzalez-Palacios

Andrew A Meharg

Affiliations

Soon will be listed here.

Abstract

Inorganic arsenic (i-As) is a non-threshold human carcinogen that has been associated with several adverse health outcomes. Exposure to i-As is of particular concern among pregnant women, infants and children, as they are specifically vulnerable to the adverse health effects of i-As, and in utero and early-life exposure, even low to moderate levels of i-As, may have a marked effect throughout the lifespan. Ion chromatography-mass spectrometry detection (IC-ICP-MS) was used to analyse urinary arsenic speciation, as an exposure biomarker, in samples of 4-year-old children with relatively low-level arsenic exposure living in different regions in Spain including Asturias, Gipuzkoa, Sabadell and Valencia. The profile of arsenic metabolites in urine was also determined in samples taken during pregnancy (1st trimester) and in the children from Valencia of 7 years old. The median of the main arsenic species found in the 4-year-old children was 9.71 μg/l (arsenobetaine-AsB), 3.97 μg/l (dimethylarsinic acid-DMA), 0.44 μg/l (monomethylarsonic acid-MMA) and 0.35 μg/l (i-As). Statistically significant differences were found in urinary AsB, MMA and i-As according to the study regions in the 4-year-old, and also in DMA among pregnant women and their children. Spearman's correlation coefficient among urinary arsenic metabolites was calculated, and, in general, a strong methylation capacity to methylate i-As to MMA was observed.

Citing Articles

Arsenic exposure and respiratory outcomes during childhood in the INMA study.

Signes-Pastor A, Diaz-Coto S, Martinez-Camblor P, Carey M, Soler-Blasco R, Garcia-Villarino M PLoS One. 2022; 17(9):e0274215.

PMID: 36083997 PMC: 9462567. DOI: 10.1371/journal.pone.0274215.

Biomonitoring of inorganic arsenic species in pregnancy.

Ashley-Martin J, Fisher M, Belanger P, Mihai Cirtiu C, Arbuckle T J Expo Sci Environ Epidemiol. 2022; 33(6):921-932.

PMID: 35948664 PMC: 10733137. DOI: 10.1038/s41370-022-00457-2.

Associations of maternal urinary arsenic concentrations during pregnancy with childhood cognitive abilities: The HOME study.

Signes-Pastor A, Romano M, Jackson B, Braun J, Yolton K, Chen A Int J Hyg Environ Health. 2022; 245:114009.

PMID: 35947921 PMC: 9500348. DOI: 10.1016/j.ijheh.2022.114009.

Exposure to metal mixture and growth indicators at 4-5 years. A study in the INMA-Asturias cohort.

Garcia-Villarino M, Signes-Pastor A, Karagas M, Riano-Galan I, Rodriguez-Dehli C, Grimalt J Environ Res. 2021; 204(Pt D):112375.

PMID: 34785205 PMC: 8671344. DOI: 10.1016/j.envres.2021.112375.

Prenatal exposure to arsenic and lung function in children from the New Hampshire Birth Cohort Study.

Signes-Pastor A, Martinez-Camblor P, Baker E, Madan J, Guill M, Karagas M Environ Int. 2021; 155:106673.

PMID: 34091160 PMC: 8353991. DOI: 10.1016/j.envint.2021.106673.

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