The Role of Toll-Like Receptors in Autoimmune Diseases Through Failure of the Self-Recognition Mechanism

Overview

Journal Int J Inflam

Publisher Wiley

Date 2017 May 30

PMID 28553556

Citations 58

Authors

Mark Farrugia

Byron Baron

Affiliations

Soon will be listed here.

Abstract

Toll-like receptors (TLRs), part of the innate immune system that recognises molecular signatures, are important in the recognition of pathogenic components. However, when specific cellular contexts develop in which TLRs are inappropriately activated by self-components, this may lead to sterile inflammation and result in the occurrence of autoimmunity. This review analyses the available data regarding TLR biochemistry, the specific mechanisms which are brought about by TLR activation, and the importance of these mechanisms in the light of any existing and potential therapies in the field of autoimmunity.

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