Aqueous Proinflammatory Cytokines in Acute Primary Angle-closure Eyes

Overview

Journal Int J Ophthalmol

Specialty Ophthalmology

Date 2017 May 27

PMID 28546929

Citations 3

Authors

Yao-Ming Liu

Shi-Da Chen

Xing-Yi Li

Wen-Bin Huang

Fei Li

Jia-Wei Wang

Ying-Qi Li

Xiu-Lan Zhang

Affiliations

Soon will be listed here.

Abstract

Aim: To evaluate changes of proinflammatory cytokines in aqueous humor of patients with acute primary angle-closure (APAC) and age-related cataracts.

Methods: Twenty eyes of 20 APAC patients and 15 eyes of 15 age-related cataract patients were included in this cross-sectional study. Aqueous humor samples were collected prospectively. The levels of 20 proinflammatory cytokines were evaluated in the aqueous humor of the APAC and cataract patients using the multiplex bead immunoassay technique. Clinical data were collected for correlation analysis.

Results: Seven of the 20 proinflammatory cytokines included in the magnetic bead panel were detectable in both APAC eyes and cataract eyes: interleukin (IL)-10, IL-12, IL-15, IL-21, IL-6, chemokine (C-C motif) ligand 20, and tumor necrosis factor alpha (TNF-α). IL-27 was only detectable in APAC eyes. Compared with the cataract eyes, the APAC eyes had significantly elevated concentrations of IL-12 (=0.036), IL-15 (=0.001), IL-6 (=0.012), and IL-27 (only detectable in APAC eyes). Age was positively correlated with IL-12 (=0.022) and IL-6 (=0.037), and time elapsed between APAC onset and aqueous humor samples collection was positively correlated with IL-15 (=0.037), IL-27 (=0.040), and TNF-α (=0.042).

Conclusion: Several proinflammatory cytokines including IL-12, IL-15, IL-6 and IL-27, were elevated in the APAC eyes and may be implicated in its pathologic mechanism.

Citing Articles

The inflammatory cytokine profiles and ocular biometric characteristics of primary angle-closure glaucoma.

Zeng H, Jiang J, Li R, Li J, Zeng W, Li X J Int Med Res. 2023; 51(1):3000605221147434.

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The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis.

Ulhaq Z, Soraya G, Budu , Wulandari L Sci Rep. 2020; 10(1):17453.

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Inflammatory cytokine profiles in eyes with primary angle-closure glaucoma.

Wang Y, Chen S, Liu Y, Huang W, Li X, Zhang X Biosci Rep. 2018; 38(6).

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