Effect of Variable Antidiabetic Treatments Strategy on Oxidative Stress Markers in Obese Patients with T2DM

Overview

Journal Diabetol Metab Syndr

Publisher Biomed Central

Specialty Endocrinology

Date 2017 May 27

PMID 28546831

Citations 4

Authors

Abeer A Alrefai

Alsayed M Alsalamony

Sameer H Fatani

Hala F M Kamel

Affiliations

Soon will be listed here.

Abstract

Aim: To evaluate the effect of different anti-diabetic treatment strategy on oxidative stress markers in patients with type 2 diabetes mellitus (T2DM).

Subject And Methods: A total of 93 patients with T2DM treated with metformin (G1 = 25), OHA (G2 = 22), OA and insulin (G3 = 26) and insulin alone (G4 = 20). In all patients, lipid profile and glycemic indices were assessed using routine laboratory tests. MDA and Oxidized LDL were assessed using commercially available ELISA kits. Laboratory tests were performed at baseline and at a control visit after 24 weeks of treatment.

Results: A significant decrease in the levels of MDA with improvement of glycemic control was observed in the group receiving OHA in combination with insulin therapy. A similar decrease of oxLDL was observed in all diabetic subgroups with borderline significance in those receiving metformin alone. The remaining clinical and biochemical parameters were not changed during follow-up in any of the involved groups.

Conclusion: A combination therapy with insulin was more effective in glycemic control and MDA reduction in T2DM. Whereas, a significant oxLDLc reduction was observed in T2DM irrespective of categories of antidiabetic treatment or glycemic control.

Citing Articles

Biomarkers of Oxidative Stress and Their Clinical Relevance in Type 2 Diabetes Mellitus Patients: A Systematic Review.

S S, Hegde S, Agarwal S, Ns D, Pillai A, Shah S Cureus. 2024; 16(8):e66570.

PMID: 39252730 PMC: 11382618. DOI: 10.7759/cureus.66570.

How Diabetes and Other Comorbidities of Elderly Patients and Their Treatment Influence Levels of Glycation Products.

Kuzan A, Krolewicz E, Kustrzeba-Wojcicka I, Lindner-Pawlowicz K, Sobieszczanska M Int J Environ Res Public Health. 2022; 19(12).

PMID: 35742776 PMC: 9223786. DOI: 10.3390/ijerph19127524.

Association of antidiabetic therapy with shortened telomere length in middle-aged Type 2 diabetic patients.

Al-Thuwaini T J Diabetes Metab Disord. 2021; 20(2):1161-1168.

PMID: 34900769 PMC: 8630347. DOI: 10.1007/s40200-021-00835-x.

Glycemic variability is associated with myocardial damage in nondiabetic patients with ST-elevation myocardial infarction.

Oka S, Deyama J, Umetani K, Harama T, Shimizu T, Makino A Cardiovasc Endocrinol Metab. 2019; 7(2):47-53.

PMID: 31646280 PMC: 6739848. DOI: 10.1097/XCE.0000000000000145.

References

Aouacheri O, Saka S, Krim M, Messaadia A, Maidi I . The investigation of the oxidative stress-related parameters in type 2 diabetes mellitus. Can J Diabetes. 2014; 39(1):44-9. DOI: 10.1016/j.jcjd.2014.03.002. View

Ahmed N . Advanced glycation endproducts--role in pathology of diabetic complications. Diabetes Res Clin Pract. 2004; 67(1):3-21. DOI: 10.1016/j.diabres.2004.09.004. View

Yan M, Mehta J, Zhang W, Hu C . LOX-1, oxidative stress and inflammation: a novel mechanism for diabetic cardiovascular complications. Cardiovasc Drugs Ther. 2011; 25(5):451-9. DOI: 10.1007/s10557-011-6342-4. View

Verges B . New insight into the pathophysiology of lipid abnormalities in type 2 diabetes. Diabetes Metab. 2005; 31(5):429-39. DOI: 10.1016/s1262-3636(07)70213-6. View

Moon J, Karunakaran U, Elumalai S, Lee I, Lee H, Kim Y . Metformin prevents glucotoxicity by alleviating oxidative and ER stress-induced CD36 expression in pancreatic beta cells. J Diabetes Complications. 2016; 31(1):21-30. DOI: 10.1016/j.jdiacomp.2016.09.001. View

Kang H, Kim D . Body mass index and waist circumference according to glucose tolerance status in Korea: the 2005 Korean Health and Nutrition Examination Survey. J Korean Med Sci. 2012; 27(5):518-24. PMC: 3342543. DOI: 10.3346/jkms.2012.27.5.518. View

Chobanian A, Bakris G, Black H, Cushman W, Green L, Izzo Jr J . Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003; 42(6):1206-52. DOI: 10.1161/01.HYP.0000107251.49515.c2. View

Schupp N, Schmid U, Heidland A, Stopper H . Rosuvastatin protects against oxidative stress and DNA damage in vitro via upregulation of glutathione synthesis. Atherosclerosis. 2007; 199(2):278-87. DOI: 10.1016/j.atherosclerosis.2007.11.016. View

Matough F, Budin S, Hamid Z, Alwahaibi N, Mohamed J . The role of oxidative stress and antioxidants in diabetic complications. Sultan Qaboos Univ Med J. 2012; 12(1):5-18. PMC: 3286717. DOI: 10.12816/0003082. View

10.

Wright Jr E, Scism-Bacon J, GLASS L . Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia. Int J Clin Pract. 2006; 60(3):308-14. PMC: 1448694. DOI: 10.1111/j.1368-5031.2006.00825.x. View

11.

Reddy V, Agrawal P, Sethi S, Gupta N, Garg R, Madaan H . Associations of FPG, A1C and disease duration with protein markers of oxidative damage and antioxidative defense in type 2 diabetes and diabetic retinopathy. Eye (Lond). 2015; 29(12):1585-93. PMC: 5129785. DOI: 10.1038/eye.2015.177. View

12.

Petrie J, Chaturvedi N, Ford I, Hramiak I, Hughes A, Jenkins A . Metformin in adults with type 1 diabetes: Design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): An international multicentre trial. Diabetes Obes Metab. 2016; 19(4):509-516. PMC: 5357575. DOI: 10.1111/dom.12840. View

13.

Odegaard A, Jacobs Jr D, Sanchez O, Goff Jr D, Reiner A, Gross M . Oxidative stress, inflammation, endothelial dysfunction and incidence of type 2 diabetes. Cardiovasc Diabetol. 2016; 15:51. PMC: 4806507. DOI: 10.1186/s12933-016-0369-6. View

14.

Gerstein H, Miller M, Byington R, Goff Jr D, Thomas Bigger J, Buse J . Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008; 358(24):2545-59. PMC: 4551392. DOI: 10.1056/NEJMoa0802743. View

15.

Silvares R, da Silva Pereira E, Flores E, Estato V, Reis P, da Silva I . Combined therapy with metformin and insulin attenuates systemic and hepatic alterations in a model of high-fat diet-/streptozotocin-induced diabetes. Int J Exp Pathol. 2016; 97(3):266-77. PMC: 4960575. DOI: 10.1111/iep.12184. View

16.

Pazdro R, Burgess J . The role of vitamin E and oxidative stress in diabetes complications. Mech Ageing Dev. 2010; 131(4):276-86. DOI: 10.1016/j.mad.2010.03.005. View

17.

Monnier L, Colette C, Michel F, Cristol J, Owens D . Insulin therapy has a complex relationship with measure of oxidative stress in type 2 diabetes: a case for further study. Diabetes Metab Res Rev. 2011; 27(4):348-53. DOI: 10.1002/dmrr.1174. View

18.

. Standards of medical care in diabetes-2015 abridged for primary care providers. Clin Diabetes. 2015; 33(2):97-111. PMC: 4398006. DOI: 10.2337/diaclin.33.2.97. View

19.

Guariguata L, Whiting D, Hambleton I, Beagley J, Linnenkamp U, Shaw J . Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 2014; 103(2):137-49. DOI: 10.1016/j.diabres.2013.11.002. View

20.

Zhang X, Liu Y, Xiong D, Xie C . Insulin combined with Chinese medicine improves glycemic outcome through multiple pathways in patients with type 2 diabetes mellitus. J Diabetes Investig. 2015; 6(6):708-15. PMC: 4627549. DOI: 10.1111/jdi.12352. View