Dose-dependent Effect of Silver Nanoparticles (AgNPs) on Fertility and Survival of Drosophila: An In-vivo Study

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 May 26

PMID 28542630

Citations 26

Authors

Akanksha Raj

Prasanna Shah

Namita Agrawal

Affiliations

Soon will be listed here.

Abstract

Silver nanoparticles (AgNPs) containing consumer products have been proliferating in the market due to its unique antimicrobial property, however, lack of in-depth knowledge about their potential effect on human health in a longer run is of great concern. Therefore, we investigated dose-dependent in vivo effect of AgNPs using Drosophila as a model system. Drosophila, a genetically tractable organism with distinct developmental stages, short life cycle and significant homology with human serves as an ideal organism to study nanomaterial-mediated toxicity. Our studies suggest that ingestion of AgNPs in Drosophila during adult stage for short and long duration significantly affects egg laying capability along with impaired growth of ovary. Additionally, dietary intake of AgNPs from larval stage has more deleterious effects that result in reduced survival, longevity, ovary size and egg laying capability at a further lower dosage. Interestingly, the trans-generational effect of AgNPs was also observed without feeding progeny with AgNPs, thereby suggesting its impact from previous generation. Our results strongly imply that higher doses of AgNPs and its administration early during development is detrimental to the reproductive health and survival of Drosophila that follows in generations to come without feeding them to AgNPs.

Citing Articles

Reproductive Toxicity of Nanomaterials Using Silver Nanoparticles and as Models.

Alaraby M, Abass D, Gutierrez J, Velazquez A, Hernandez A, Marcos R Molecules. 2024; 29(23).

PMID: 39683959 PMC: 11643907. DOI: 10.3390/molecules29235802.

Silver Nanoparticles in Therapeutics and Beyond: A Review of Mechanism Insights and Applications.

Eker F, Duman H, Akdasci E, Witkowska A, Bechelany M, Karav S Nanomaterials (Basel). 2024; 14(20).

PMID: 39452955 PMC: 11510578. DOI: 10.3390/nano14201618.

Bugs on Drugs: Paracetamol Exposure Reveals Genotype-Specific Generational Effects on Life History Traits in .

Hundebol B, Rohde P, Kristensen T, Jensen R, Vosegaard T, Sorensen J Insects. 2024; 15(10).

PMID: 39452339 PMC: 11509061. DOI: 10.3390/insects15100763.

Mapping a sustainable approach: biosynthesis of lactobacilli-silver nanocomposites using whey-based medium for antimicrobial and bioactivity applications.

El Fadly E, Salah A, Abdella B, Al Ali A, AlShmrany H, ElBaz A Microb Cell Fact. 2024; 23(1):195.

PMID: 38971787 PMC: 11227706. DOI: 10.1186/s12934-024-02428-8.

The reprotoxic adverse side effects of neurogenic and neuroprotective drugs: current use of human organoid modeling as a potential alternative to preclinical models.

Abady M, Jeong J, Kwon H, Assiri A, Cho J, Saadeldin I Front Pharmacol. 2024; 15:1412188.

PMID: 38948466 PMC: 11211546. DOI: 10.3389/fphar.2024.1412188.

References

Wu Y, Zhou Q, Li H, Liu W, Wang T, Jiang G . Effects of silver nanoparticles on the development and histopathology biomarkers of Japanese medaka (Oryzias latipes) using the partial-life test. Aquat Toxicol. 2009; 100(2):160-7. DOI: 10.1016/j.aquatox.2009.11.014. View

Ju-Nam Y, Lead J . Manufactured nanoparticles: an overview of their chemistry, interactions and potential environmental implications. Sci Total Environ. 2008; 400(1-3):396-414. DOI: 10.1016/j.scitotenv.2008.06.042. View

Kim J, Kuk E, Yu K, Kim J, Park S, Lee H . Antimicrobial effects of silver nanoparticles. Nanomedicine. 2007; 3(1):95-101. DOI: 10.1016/j.nano.2006.12.001. View

Moon J, Kwak J, Kim S, An Y . Multigenerational effects of gold nanoparticles in Caenorhabditis elegans: Continuous versus intermittent exposures. Environ Pollut. 2016; 220(Pt A):46-52. DOI: 10.1016/j.envpol.2016.09.021. View

Kim K, Truong L, Wehmas L, Tanguay R . Silver nanoparticle toxicity in the embryonic zebrafish is governed by particle dispersion and ionic environment. Nanotechnology. 2013; 24(11):115101. PMC: 3782284. DOI: 10.1088/0957-4484/24/11/115101. View

Spradling A . Stem cells and their progeny respond to nutritional changes during Drosophila oogenesis. Dev Biol. 2001; 231(1):265-78. DOI: 10.1006/dbio.2000.0135. View

Arora S, Jain J, Rajwade J, Paknikar K . Cellular responses induced by silver nanoparticles: In vitro studies. Toxicol Lett. 2008; 179(2):93-100. DOI: 10.1016/j.toxlet.2008.04.009. View

Braydich-Stolle L, Hussain S, Schlager J, Hofmann M . In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci. 2005; 88(2):412-9. PMC: 2911231. DOI: 10.1093/toxsci/kfi256. View

Ahamed M, Posgai R, Gorey T, Nielsen M, Hussain S, Rowe J . Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster. Toxicol Appl Pharmacol. 2009; 242(3):263-9. DOI: 10.1016/j.taap.2009.10.016. View

10.

Kim S, Ryu D . Silver nanoparticle-induced oxidative stress, genotoxicity and apoptosis in cultured cells and animal tissues. J Appl Toxicol. 2012; 33(2):78-89. DOI: 10.1002/jat.2792. View

11.

Ahamed M, Karns M, Goodson M, Rowe J, Hussain S, Schlager J . DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells. Toxicol Appl Pharmacol. 2008; 233(3):404-10. DOI: 10.1016/j.taap.2008.09.015. View

12.

Buszczak M, Freeman M, Carlson J, Bender M, Cooley L, Segraves W . Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila. Development. 1999; 126(20):4581-9. DOI: 10.1242/dev.126.20.4581. View

13.

Sondi I, Salopek-Sondi B . Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. J Colloid Interface Sci. 2004; 275(1):177-82. DOI: 10.1016/j.jcis.2004.02.012. View

14.

Arora S, Jain J, Rajwade J, Paknikar K . Interactions of silver nanoparticles with primary mouse fibroblasts and liver cells. Toxicol Appl Pharmacol. 2009; 236(3):310-8. DOI: 10.1016/j.taap.2009.02.020. View

15.

Ahamed M, Alsalhi M, Siddiqui M . Silver nanoparticle applications and human health. Clin Chim Acta. 2010; 411(23-24):1841-8. DOI: 10.1016/j.cca.2010.08.016. View

16.

Poma A, Colafarina S, Fontecchio G, Chichiricco G . Transgenerational effects of NMs. Adv Exp Med Biol. 2014; 811:235-54. DOI: 10.1007/978-94-017-8739-0_12. View

17.

Muangman P, Chuntrasakul C, Silthram S, Suvanchote S, Benjathanung R, Kittidacha S . Comparison of efficacy of 1% silver sulfadiazine and Acticoat for treatment of partial-thickness burn wounds. J Med Assoc Thai. 2006; 89(7):953-8. View

18.

Demir E, Vales G, Kaya B, Creus A, Marcos R . Genotoxic analysis of silver nanoparticles in Drosophila. Nanotoxicology. 2010; 5(3):417-24. DOI: 10.3109/17435390.2010.529176. View

19.

Furno F, Morley K, Wong B, Sharp B, Arnold P, Howdle S . Silver nanoparticles and polymeric medical devices: a new approach to prevention of infection?. J Antimicrob Chemother. 2004; 54(6):1019-24. DOI: 10.1093/jac/dkh478. View

20.

Liu X, Lee P, Ho C, Lui V, Chen Y, Che C . Silver nanoparticles mediate differential responses in keratinocytes and fibroblasts during skin wound healing. ChemMedChem. 2010; 5(3):468-75. DOI: 10.1002/cmdc.200900502. View