Less Invasive Surfactant Administration Reduces the Need for Mechanical Ventilation in Preterm Infants: A Meta-Analysis

Overview

Journal Glob Pediatr Health

Specialty Pediatrics

Date 2017 May 26

PMID 28540346

Citations 21

Authors

Christine S M Lau

Ronald S Chamberlain

Shyan Sun

Affiliations

Soon will be listed here.

Abstract

Neonatal respiratory distress syndrome due to surfactant deficiency is associated with high morbidity and mortality in preterm infants, and the use of less invasive surfactant administration (LISA) has been increasingly studied. This meta-analysis found that LISA via thin catheter significantly reduced the need for mechanical ventilation within the first 72 hours (relative risk [RR] = 0.677; = .021), duration of mechanical ventilation (difference in means [MD] = -39.302 hours; < .001), duration of supplemental oxygen (MD = -68.874 hours; < .001), and duration of nasal continuous positive airway pressure (nCPAP; MD = -28.423 hours; = .010). A trend toward a reduction in the incidence of bronchopulmonary dysplasia was observed (RR = 0.656; = .141). No significant difference in overall mortality, incidence of pneumothorax, or successful first attempts was observed. LISA via thin catheter significantly reduces the need for mechanical ventilation within the first 72 hours as well as the duration of mechanical ventilation, supplemental oxygen, and nCPAP. LISA via thin catheter appears promising in improving preterm infant outcomes.

Citing Articles

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Less Invasive Surfactant Administration Compared to Intubation, Surfactant, Rapid Extubation Method in Preterm Neonates: An Umbrella Review.

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Comparison of Outcomes of Less Invasive Surfactant Administration in Prematurely Born Infants in the Delivery Suite and the Neonatal Unit.

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Prevention of Chronic Morbidities in Extremely Premature Newborns with LISA-nCPAP Respiratory Therapy and Adjuvant Perinatal Strategies.

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