Prosthetic Joint Infection. A Review of Treatment Methods

Overview

Journal J Bone Jt Infect

Date 2017 May 26

PMID 28540147

Citations 26

Authors

Fernando Cobo

Javier Rodriguez-Granger

Antonio Sampedro

Luis Aliaga-Martinez

Jose Maria Navarro-Mari

Affiliations

Soon will be listed here.

Abstract

Fungal microorganisms are still a rare cause of bone and joint infections. We report a new case of knee prosthetic joint infection due to in a patient with a previous two-stage right knee arthroplasty for septic arthritis due to occurred several months ago. Moreover, the treatment in 76 cases of prosthetic joint infection has been discussed. Forty patients were female and mean age at diagnosis was 65.7 (± SD 18) yrs. No risk factors for candidal infection were found in 25 patients. Infection site was the knee in 38 patients and hip in 36; pain was present in 44 patients and swelling in 24. The most frequent species was , followed by . Eleven patients were only treated with antifungal drugs being the outcome favourable in all of them. Two-stage exchange arthroplasty was performed in 30 patients, and resection arthroplasty in other 30; in three patients one-stage exchange arthroplasty was done. A favourable outcome was found in 58 patients after antifungal plus surgical treatment, in 11 after antifungal treatment alone and in one after surgery alone. The type of treatment is still not clearly defined and an algorithm for treatment in fungal PJI should be established, but various types of surgical procedures may be applied.

Citing Articles

Prosthetic Joint Infections due to Candida Species: A Multicenter International Study.

Dinh A, McNally M, DAnglejan E, Mamona Kilu C, Lourtet J, Ho R Clin Infect Dis. 2024; 80(2):347-355.

PMID: 39189831 PMC: 11848259. DOI: 10.1093/cid/ciae395.

Is Silver Addition to Scaffolds Based on Polycaprolactone Blended with Calcium Phosphates Able to Inhibit and Adhesion and Biofilm Formation?.

Menotti F, Scutera S, Maniscalco E, Coppola B, Bondi A, Costa C Int J Mol Sci. 2024; 25(5).

PMID: 38474027 PMC: 10931636. DOI: 10.3390/ijms25052784.

Novel Local Antifungal Treatment for Fungal Periprosthetic Joint Infection With Continuous Local Antibiotic Perfusion: A Surgical Technique.

Choe H, Maruo A, Hieda Y, Abe K, Kobayashi N, Ike H Arthroplast Today. 2023; 24:101245.

PMID: 38023642 PMC: 10665700. DOI: 10.1016/j.artd.2023.101245.

Epidemiology of Fungal Periprosthetic Joint Infection: A Systematic Review of the Literature.

Sambri A, Zunarelli R, Fiore M, Bortoli M, Paolucci A, Filippini M Microorganisms. 2023; 11(1).

PMID: 36677376 PMC: 9864285. DOI: 10.3390/microorganisms11010084.

Osteoarticular Mycoses.

Gamaletsou M, Rammaert B, Brause B, Bueno M, Dadwal S, Henry M Clin Microbiol Rev. 2022; 35(4):e0008619.

PMID: 36448782 PMC: 9769674. DOI: 10.1128/cmr.00086-19.

References

Reddy K, Shah J, Kale R, Reddy T . Fungal prosthetic joint infection after total knee arthroplasty. Indian J Orthop. 2013; 47(5):526-9. PMC: 3796930. DOI: 10.4103/0019-5413.118213. View

Tande A, Patel R . Prosthetic joint infection. Clin Microbiol Rev. 2014; 27(2):302-45. PMC: 3993098. DOI: 10.1128/CMR.00111-13. View

Bartalesi F, Fallani S, Salomoni E, Marcucci M, Meli M, Pecile P . Candida glabrata prosthetic hip infection. Am J Orthop (Belle Mead NJ). 2013; 41(11):500-5. View

Ulrich S, Seyler T, Bennett D, Delanois R, Saleh K, Thongtrangan I . Total hip arthroplasties: what are the reasons for revision?. Int Orthop. 2007; 32(5):597-604. PMC: 2551710. DOI: 10.1007/s00264-007-0364-3. View

Dale H, Fenstad A, Hallan G, Havelin L, Furnes O, Overgaard S . Increasing risk of prosthetic joint infection after total hip arthroplasty. Acta Orthop. 2012; 83(5):449-58. PMC: 3488170. DOI: 10.3109/17453674.2012.733918. View

Tunkel A, Thomas C, Wispelwey B . Candida prosthetic arthritis: report of a case treated with fluconazole and review of the literature. Am J Med. 1993; 94(1):100-3. DOI: 10.1016/0002-9343(93)90127-b. View

Melo A, Bizerra F, Freymuller E, Arthington-Skaggs B, Colombo A . Biofilm production and evaluation of antifungal susceptibility amongst clinical Candida spp. isolates, including strains of the Candida parapsilosis complex. Med Mycol. 2010; 49(3):253-62. DOI: 10.3109/13693786.2010.530032. View

Graw B, Woolson S, Huddleston J . Candida infection in total knee arthroplasty with successful reimplantation. J Knee Surg. 2011; 23(3):169-74. DOI: 10.1055/s-0030-1267470. View

Marra F, Robbins G, Masri B, Duncan C, Wasan K, KWONG E . Amphotericin B-loaded bone cement to treat osteomyelitis caused by Candida albicans. Can J Surg. 2001; 44(5):383-6. PMC: 3692647. View

10.

Evans R, Nelson C . Staged reimplantation of a total hip prosthesis after infection with Candida albicans. A report of two cases. J Bone Joint Surg Am. 1990; 72(10):1551-3. View

11.

Wyman J, McGough R, Limbird R . Fungal infection of a total knee prosthesis: successful treatment using articulating cement spacers and staged reimplantation. Orthopedics. 2002; 25(12):1391-4; discussion 1394. DOI: 10.3928/0147-7447-20021201-19. View

12.

Ramamohan N, Zeineh N, Grigoris P, Butcher I . Candida glabrata infection after total hip arthroplasty. J Infect. 2001; 42(1):74-6. DOI: 10.1053/jinf.2000.0763. View

13.

Kuiper J, van den Bekerom M, van der Stappen J, Nolte P, Colen S . 2-stage revision recommended for treatment of fungal hip and knee prosthetic joint infections. Acta Orthop. 2013; 84(6):517-23. PMC: 3851663. DOI: 10.3109/17453674.2013.859422. View

14.

Lazzarini L, Manfrin V, de Lalla F . Candidal prosthetic hip infection in a patient with previous candidal septic arthritis. J Arthroplasty. 2004; 19(2):248-52. DOI: 10.1016/s0883-5403(03)00407-8. View

15.

Davey M, OToole G . Microbial biofilms: from ecology to molecular genetics. Microbiol Mol Biol Rev. 2000; 64(4):847-67. PMC: 99016. DOI: 10.1128/MMBR.64.4.847-867.2000. View

16.

Acikgoz Z, Sayli U, Avci S, Dogruel H, Gamberzade S . An extremely uncommon infection: Candida glabrata arthritis after total knee arthroplasty. Scand J Infect Dis. 2002; 34(5):394-6. DOI: 10.1080/00365540110080232. View

17.

Dumaine V, Eyrolle L, Baixench M, Paugam A, Larousserie F, Padoin C . Successful treatment of prosthetic knee Candida glabrata infection with caspofungin combined with flucytosine. Int J Antimicrob Agents. 2008; 31(4):398-9. DOI: 10.1016/j.ijantimicag.2007.12.001. View

18.

Zhu Y, Yue C, Huang Z, Pei F . infection following total hip arthroplasty: A case report. Exp Ther Med. 2014; 7(2):352-354. PMC: 3881042. DOI: 10.3892/etm.2013.1420. View

19.

Tsui C, Kong E, Jabra-Rizk M . Pathogenesis of Candida albicans biofilm. Pathog Dis. 2016; 74(4):ftw018. PMC: 5975230. DOI: 10.1093/femspd/ftw018. View

20.

Hennessy M . Infection of a total knee arthroplasty by Candida parapsilosis. A case report of successful treatment by joint reimplantation with a literature review. Am J Knee Surg. 1996; 9(3):133-6. View