Biosynthesis of ZnO Nanoparticles by a New Pichia Kudriavzevii Yeast Strain and Evaluation of Their Antimicrobial and Antioxidant Activities

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2017 May 25

PMID 28538674

Citations 33

Authors

Amin Boroumand Moghaddam

Mona Moniri

Susan Azizi

Raha Abdul Rahim

Arbakariya Bin Ariff

Wan Zuhainis Saad

Farideh Namvar

Mohammad Navaderi

Affiliations

Soon will be listed here.

Abstract

The potential ability of a new yeast strain, , in the synthesis of zinc oxide nanoparticles (ZnO-NPs) through a green method was explored in this study. The effect of reaction time (12, 24 and 36 h) on the structure of the resulting ZnO nanoparticles was investigated. From the XRD and TEM results, the ZnO-NPs with a hexagonal wurtzite structure and a particle crystal size of ~10-61 nm was formed at different reaction times. Combing XRD, TEM, and PL results, it was revealed that the sample prepared at intermediate duration (24 h) has the most favorable nanosized structure with the lowest defect concentration. The biomedical properties of ZnO-NPs as free radical scavenging activity, cytotoxicity and antibacterial agents were characterized. Biosynthesized ZnO-NPs showed strong DPPH free radical scavenging and a dose dependent toxicity with non-toxic effects on Vero cells for concentrations below 190 µg/mL. Desirable bactericidal activity was shown by the ZnO-NPs on Gram-positive bacteria (, and and Gram-negative bacteria ( and ). A maximum inhibition zone of ~19 mm was observed for at a concentration of 100 µg/mL for sample prepared at 24 h The results from this study reveal that ZnO-NPs possesses potential for many medical and industrial applications.

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