Amyloid Precursor Like Protein-1 Promotes JNK-mediated Cell Migration in Drosophila

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 May 25

PMID 28537903

Citations 2

Authors

Xingjun Wang

Ying Sun

Shilong Han

Chenxi Wu

Yeqing Ma

Yu Zhao

Yingyao Shao

Yujun Chen

Lingzhi Kong

Wenzhe Li

Fan Zhang

Lei Xue

Affiliations

Soon will be listed here.

Abstract

The amyloid precursor like protein-1 (APLP1) is a member of the amyloid precursor protein (APP) family in mammals. While many studies have been focused on the pathologic role of APP in Alzheimer's disease, the physiological functions of APLP1 have remained largely elusive. Here we report that ectopic expression of APLP1 in Drosophila induces cell migration, which is suppressed by the loss of JNK signaling and enhanced by the gain of JNK signaling. APLP1 activates JNK signaling through phosphorylation of JNK, which up-regulates the expression of matrix metalloproteinase MMP1 required for basement membranes degradation and promotes actin remodeling essential for cell migration. Our data thus provide the first in vivo evidence for a cell-autonomous role of APLP1 protein in migration.

Citing Articles

Pontin/Tip49 acts as a novel regulator of JNK pathway.

Wang X, Huang X, Wu C, Xue L Cell Death Dis. 2018; 9(10):978.

PMID: 30250132 PMC: 6155171. DOI: 10.1038/s41419-018-0977-z.

APLP2 Modulates JNK-Dependent Cell Migration in .

Wang X, Guo X, Ma Y, Wu C, Li W, Xue L Biomed Res Int. 2018; 2018:7469714.

PMID: 30155482 PMC: 6093063. DOI: 10.1155/2018/7469714.

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