Targeting Adult Neurogenesis to Optimize Hippocampal Circuits in Aging

Overview

Journal Neurotherapeutics

Specialty Neurology

Date 2017 May 25

PMID 28536851

Citations 29

Authors

Kathleen M McAvoy

Amar Sahay

Affiliations

Soon will be listed here.

Abstract

Millions of individuals suffer from age-related cognitive decline, defined by impaired memory precision. Increased understanding of hippocampal circuit mechanisms underlying memory formation suggests a role for computational processes such as pattern separation and pattern completion in memory precision. We describe evidence implicating the dentate gyrus-CA3 circuit in pattern separation and completion, and examine alterations in dentate gyrus-CA3 circuit structure and function with aging. We discuss the role of adult hippocampal neurogenesis in memory precision in adulthood and aging, as well as the circuit mechanisms underlying the integration and encoding functions of adult-born dentate granule cells. We posit that understanding these circuit mechanisms will permit generation of circuit-based endophenotypes that will edify new therapeutic strategies to optimize hippocampal encoding during aging.

Citing Articles

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An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience.

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Restoration of neuronal progenitors by partial reprogramming in the aged neurogenic niche.

Xu L, Ramirez-Matias J, Hauptschein M, Sun E, Lunger J, Buckley M Nat Aging. 2024; 4(4):546-567.

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