Review of Heterotopic Thyroid Autotransplantation

Overview

Journal Clin Exp Otorhinolaryngol

Date 2017 May 24

PMID 28535579

Citations 5

Authors

Mahmoud Sakr

Ahmed Mahmoud

Affiliations

Soon will be listed here.

Abstract

Total thyroidectomy is increasingly accepted for the management of bilateral benign thyroid disorders. Postoperatively, patients require lifelong levothyroxine replacement therapy to avoid postoperative hypothyroidism, which besides the burden of compliance, has been proven to be associated with several long-term side effects. Heterotopic thyroid autotransplantation was proposed several decades ago to avoid the need for life-long postoperative replacement therapy with maintaining the autoregulatory mechanism of thyroxin production inside the body according to its needs. Available data regarding this topic in literature is relatively poor. Before applying thyroid autotransplantation on humans, several studies have been done on animals, where the autologous transplantations were found to be successful in almost all the cases, proved by follow up postoperative 8-week measurements of thyroid hormones and histopathological examination of the removed autografts. Regarding the clinical application, few trials have been done using cryopreserved in vivo, in vitro or immediately autotransplanted thyroid autografts. Satisfactory results were obtained, however, the number of these studies and the number of patients per each study was very low. Besides the study methodologies were not so consistent.

Citing Articles

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References

Faber J, Galloe A . Changes in bone mass during prolonged subclinical hyperthyroidism due to L-thyroxine treatment: a meta-analysis. Eur J Endocrinol. 1994; 130(4):350-6. DOI: 10.1530/eje.0.1300350. View

Sethi M, Parr M, Bhatia V . Management strategies for hypothyroidism in non-compliant patients: a case report and review of literature. S D Med. 2008; 61(10):368-9. View

NORTHCUTT R, Stiel J, Hollifield J, STANT Jr E . The influence of cholestyramine on thyroxine absorption. JAMA. 1969; 208(10):1857-61. View

Centanni M . Thyroxine treatment: absorption, malabsorption, and novel therapeutic approaches. Endocrine. 2012; 43(1):8-9. DOI: 10.1007/s12020-012-9814-9. View

Rabkin J, Olyaei A, Orloff S, Geisler S, Wahoff D, Hering B . Distant processing of pancreas islets for autotransplantation following total pancreatectomy. Am J Surg. 1999; 177(5):423-7. DOI: 10.1016/s0002-9610(99)00078-1. View

Stoffer S, Szpunar W . Potency of current levothyroxine preparations evaluated by high-performance liquid chromatography. Henry Ford Hosp Med J. 1988; 36(1):64-5. View

Mohsen A, Nada A, Ibrahim M, Ghaleb A, Abou-Gabal M, Mohsen A . Technique and outcome of autotransplanting thyroid tissue after total thyroidectomy for simple multinodular goiters. Asian J Surg. 2015; 40(1):17-22. DOI: 10.1016/j.asjsur.2015.05.007. View

Papaziogas B, Antoniadis A, Lazaridis C, Makris J, Kotakidou R, Paraskevas G . Functional capacity of the thyroid autograft: an experimental study. J Surg Res. 2002; 103(2):223-7. DOI: 10.1006/jsre.2001.6348. View

Monzani F, Caraccio N, Kozakowa M, Dardano A, Vittone F, Virdis A . Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo- controlled study. J Clin Endocrinol Metab. 2004; 89(5):2099-106. DOI: 10.1210/jc.2003-031669. View

10.

Yu X, Chen Y, Shan Z, Teng W, Li C, Zhou W . The pattern of thyroid function of subclinical hypothyroid women with levothyroxine treatment during pregnancy. Endocrine. 2013; 44(3):710-5. DOI: 10.1007/s12020-013-9913-2. View

11.

Perros P . European thyroid association guidelines on L-t4 + L-t3 combination for hypothyroidism: a weary step in the right direction. Eur Thyroid J. 2014; 1(2):51-4. PMC: 3821462. DOI: 10.1159/000338637. View

12.

Karaman M, Tuncel A, Sheidaei S, Karabulut M, Tatlipinar A . Functional capacity of the thyroid autograft and heterograft: An experimental study. Head Neck. 2011; 34(5):702-8. DOI: 10.1002/hed.21811. View

13.

Minuto F, Fazzuoli L, Rollandi G, Derchi L, Biassoni P . Successful autotransplantation of lingual thyroid: 37-year follow-up. Lancet. 1995; 346(8979):910. DOI: 10.1016/s0140-6736(95)92758-1. View

14.

Meng R, Tang H, Westfall J, London D, Cao J, Mousa S . Crosstalk between integrin αvβ3 and estrogen receptor-α is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. PLoS One. 2011; 6(11):e27547. PMC: 3222665. DOI: 10.1371/journal.pone.0027547. View

15.

Callejo J, Jauregui M, Valls C, Fernandez M, Cabre S, Lailla J . Heterotopic ovarian transplantation without vascular pedicle in syngeneic Lewis rats: six-month control of estradiol and follicle-stimulating hormone concentrations after intraperitoneal and subcutaneous implants. Fertil Steril. 1999; 72(3):513-7. DOI: 10.1016/s0015-0282(99)00287-3. View

16.

Dobrinja C, Trevisan R, Trevisan G, Liguori G . Autotransplantation of thyroid tissue in rats. An experimental study. Ann Ital Chir. 2009; 79(5):389-95. View

17.

Schneyer C . Calcium carbonate and reduction of levothyroxine efficacy. JAMA. 1998; 279(10):750. DOI: 10.1001/jama.279.10.750-b. View

18.

Shakir K, Chute J, Aprill B, LAZARUS A . Ferrous sulfate-induced increase in requirement for thyroxine in a patient with primary hypothyroidism. South Med J. 1997; 90(6):637-9. DOI: 10.1097/00007611-199706000-00011. View

19.

Nabishah B, Khalid B, Morat P, Zanariyah A . Regeneration of adrenal cortical tissue after adrenal autotransplantation. Exp Clin Endocrinol Diabetes. 1998; 106(5):419-24. DOI: 10.1055/s-0029-1212009. View

20.

Havrankova J, Lahaie R . Levothyroxine binding by sucralfate. Ann Intern Med. 1992; 117(5):445-6. DOI: 10.7326/0003-4819-117-5-445_3. View