Identification of Genetic Loci Shared Between Schizophrenia and the Big Five Personality Traits

Overview

Journal Sci Rep

Specialty Science

Date 2017 May 24

PMID 28533504

Citations 31

Authors

Olav B Smeland

Yunpeng Wang

Min-Tzu Lo

Wen Li

Oleksandr Frei

Aree Witoelar

Martin Tesli

David A Hinds

Joyce Y Tung

Srdjan Djurovic

Chi-Hua Chen

Anders M Dale

Ole A Andreassen

Affiliations

Soon will be listed here.

Abstract

Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between schizophrenia and the Big Five personality traits using a Bayesian statistical framework. Using summary statistics from genome-wide association studies (GWAS) on personality traits in the 23andMe cohort (n = 59,225) and schizophrenia in the Psychiatric Genomics Consortium cohort (n = 82,315), we evaluated overlap in common genetic variants. The Big Five personality traits neuroticism, extraversion, openness, agreeableness and conscientiousness were measured using a web implementation of the Big Five Inventory. Applying the conditional false discovery rate approach, we increased discovery of genetic loci and identified two loci shared between neuroticism and schizophrenia and six loci shared between openness and schizophrenia. The study provides new insights into the relationship between personality traits and schizophrenia by highlighting genetic loci involved in their common genetic etiology.

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