Involvement of Two-Component Signaling on Bacterial Motility and Biofilm Development

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2017 May 24

PMID 28533218

Citations 45

Authors

Birgit M Pruss

Affiliations

Soon will be listed here.

Abstract

Two-component signaling is a specialized mechanism that bacteria use to respond to changes in their environment. Nonpathogenic strains of K-12 harbor 30 histidine kinases and 32 response regulators, which form a network of regulation that integrates many other global regulators that do not follow the two-component signaling mechanism, as well as signals from central metabolism. The output of this network is a multitude of phenotypic changes in response to changes in the environment. Among these phenotypic changes, many two-component systems control motility and/or the formation of biofilm, sessile communities of bacteria that form on surfaces. Motility is the first reversible attachment phase of biofilm development, followed by a so-called swim or stick switch toward surface organelles that aid in the subsequent phases. In the mature biofilm, motility heterogeneity is generated by a combination of evolutionary and gene regulatory events.

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