Morphological Changes in Peri-prostatic Sympathetic Ganglion Cells in Aging Males

Overview

Journal Mol Clin Oncol

Specialty Oncology

Date 2017 May 23

PMID 28529746

Citations 3

Authors

Lea Rath-Wolfson

Asaf Shvero

Golan Bubis

Galina Buzaverov

Aliza Zeidman

Edward Ram

Rumelia Koren

Affiliations

Soon will be listed here.

Abstract

A significant part of morbidity in elderly male patients involves the pelvic organs and their autonomic neural regulation. The aim of the current study was to report the histopathological changes in the peri-prostatic ganglia in elderly males. The sympathetic ganglia from 36 prostatectomy specimens, 26 due to carcinoma of the prostate and 10 prostates from total cystectomies for transitional cell carcinoma, were examined. The age range was 54-88 years. A total of 5,075 ganglion cells were counted in all the specimens. Pathological changes were identified in 1,696 neuron cells as follows: Neuronophagia in 746 neuron cells, neuron cell vacuolization (330 cells), satellite cells vacuolization (423 cells), cell pyknosis (148 cells) and nageotte nodules (49 cells). A number of these changes increased with age. All the changes were more marked in the peri-prostatic ganglion cells of patients with prostatic adenocarcinoma compared with those with benign prostate hyperplasia, which may be due to local environmental changes associated with the presence of malignancy.

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