Synergy of Antiviral Actions of TNF and IFN-gamma: Evidence for a Major Role of TNF-induced IFN-beta

Overview

Journal Antiviral Res

Publisher Elsevier

Date 1988 Nov 1

PMID 2852914

Citations 7

Authors

T K Hughes

T A Kaspar

D H Coppenhaver

Affiliations

Soon will be listed here.

Abstract

Tumor necrosis factor (TNF) potentiates the antiviral activity of interferon-gamma (IFN-gamma) directly and through induction of IFN-beta in HEp-2 cells. Antibody to IFN-beta inhibits a large component of the TNF and IFN-gamma synergy and immunoreactive IFN-beta can be detected in the supernatant fluids of TNF-treated HEp-2 cells. Furthermore, the kinetics of development of this synergy and its susceptibility to inhibition by antibody to IFN-beta is demonstrated.

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