Aberrant Functional Connectivity in Depression As an Index of State and Trait Rumination

Overview

Journal Sci Rep

Specialty Science

Date 2017 May 21

PMID 28526867

Citations 35

Authors

David Rosenbaum

Alina Haipt

Kristina Fuhr

Florian B Haeussinger

Florian G Metzger

Hans-Christoph Nuerk

Andreas J Fallgatter

Anil Batra

Ann-Christine Ehlis

Affiliations

Soon will be listed here.

Abstract

Depression has been shown to be related to a variety of aberrant brain functions and structures. Particularly the investigation of alterations in functional connectivity (FC) in major depressive disorder (MDD) has been a promising endeavor, since a better understanding of pathological brain networks may foster our understanding of the disease. However, the underling mechanisms of aberrant FC in MDD are largely unclear. Using functional near-infrared spectroscopy (fNIRS) we investigated FC in the cortical parts of the default mode network (DMN) during resting-state in patients with current MDD. Additionally, we used qualitative and quantitative measures of psychological processes (e.g., state/trait rumination, mind-wandering) to investigate their contribution to differences in FC between depressed and non-depressed subjects. Our results indicate that 40% of the patients report spontaneous rumination during resting-state. Depressed subjects showed reduced FC in parts of the DMN compared to healthy controls. This finding was linked to the process of state/trait rumination. While rumination was negatively correlated with FC in the cortical parts of the DMN, mind-wandering showed positive associations.

Citing Articles

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