Subcellular Energetics and Metabolism: A Cross-Species Framework

Overview

Journal Anesth Analg

Specialty Anesthesiology

Date 2017 May 20

PMID 28525507

Citations 7

Authors

Robert H Thiele

Affiliations

Soon will be listed here.

Abstract

Although it is generally believed that oxidative phosphorylation and adequate oxygenation are essential for life, human development occurs in a profoundly hypoxic environment and "normal" levels of oxygen during embryogenesis are even harmful. The ability of embryos not only to survive but also to thrive in such an environment is made possible by adaptations related to metabolic pathways. Similarly, cancerous cells are able not only to survive but also to grow and spread in environments that would typically be fatal for healthy adult cells. Many biological states, both normal and pathological, share underlying similarities related to metabolism, the electron transport chain, and reactive species. The purpose of Part I of this review is to review the similarities among embryogenesis, mammalian adaptions to hypoxia (primarily driven by hypoxia-inducible factor-1), ischemia-reperfusion injury (and its relationship with reactive oxygen species), hibernation, diving animals, cancer, and sepsis, with a particular focus on the common characteristics that allow cells and organisms to survive in these states.

Citing Articles

The Unfolded Protein Response: A Double-Edged Sword for Brain Health.

Gebert M, Slawski J, Kalinowski L, Collawn J, Bartoszewski R Antioxidants (Basel). 2023; 12(8).

PMID: 37627643 PMC: 10451475. DOI: 10.3390/antiox12081648.

The Role of the Hypoxia-Related Unfolded Protein Response (UPR) in the Tumor Microenvironment.

Bartoszewska S, Collawn J, Bartoszewski R Cancers (Basel). 2022; 14(19).

PMID: 36230792 PMC: 9562011. DOI: 10.3390/cancers14194870.

Molecular and Cellular Response of the Myocardium (H9C2 Cells) Towards Hypoxia and HIF-1α Inhibition.

Osuru H, Lavallee M, Thiele R Front Cardiovasc Med. 2022; 9:711421.

PMID: 35928940 PMC: 9343679. DOI: 10.3389/fcvm.2022.711421.

Anesthesia-Sepsis-Associated Alterations in Liver Gene Expression Profiles and Mitochondrial Oxidative Phosphorylation Complexes.

Osuru H, Paila U, Ikeda K, Zuo Z, Thiele R Front Med (Lausanne). 2021; 7:581082.

PMID: 33392215 PMC: 7775734. DOI: 10.3389/fmed.2020.581082.

IRE1 Endoribonuclease Activity Modulates Hypoxic HIF-1α Signaling in Human Endothelial Cells.

Moszynska A, Collawn J, Bartoszewski R Biomolecules. 2020; 10(6).

PMID: 32545307 PMC: 7355874. DOI: 10.3390/biom10060895.

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