Viral Hijacking of Host Caspases: an Emerging Category of Pathogen-host Interactions

Overview

Journal Cell Death Differ

Specialty Cell Biology

Date 2017 May 20

PMID 28524855

Citations 21

Authors

Patrick F Connolly

Howard O Fearnhead

Affiliations

Soon will be listed here.

Abstract

Viruses co-evolve with their hosts, and many viruses have developed mechanisms to suppress or modify the host cell apoptotic response for their own benefit. Recently, evidence has emerged for the opposite strategy. Some viruses have developed the ability to co-opt apoptotic caspase activity to facilitate their own proliferation. In these strategies, viral proteins are cleaved by host caspases to create cleavage products with novel activities which facilitate viral replication. This represents a novel and interesting class of viral-host interactions, and also represents a new group of non-apoptotic roles for caspases. Here we review the evidence for such strategies, and discuss their origins and their implications for our understanding of the relationship between viral pathogenesis and programmed cell death.

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