Exogenous Phosphatidylcholine Supplementation Retrieve Aluminum-induced Toxicity in Male Albino Rats

Overview

Journal Environ Sci Pollut Res Int

Publisher Springer

Specialties Environmental Health
Toxicology

Date 2017 May 20

PMID 28523611

Citations 11

Authors

Asmaa Fahmy Khafaga

Affiliations

Soon will be listed here.

Abstract

This study investigated the ameliorative potential of exogenous phosphatidylcholine (PC) against aluminum-induced toxicity in male albino rats. Four groups of rats were used for this study (N = 8): group I served as the control, group II (PC treated) received L-α-phosphatidylcholine (egg yolk-derived) 100 mg/kg bwt/day orally, group III (aluminum treated) received aluminum chloride 100 mg/kg bwt/day orally, and group VI (aluminum + PC treated) received similar oral dose of aluminum and PC (100 mg/kg bwt/day). Treatment was continued for 8 weeks. Results revealed that aluminum chloride treatment leading to a significant elevation in serum aspartate aminotransferase, serum alanine aminotransferase, urea, creatinine, malondialdehyde, serum cytokines (tumor necrosis factor-α, interleukin-6), and brain content of acetylcholine, as well as a significant reduction in serum-reduced glutathione, serum testosterone, and brain content of acetylcholinesterase. Moreover, aluminum administration caused significant histopathological alteration in liver, kidney, brain, testes, and epididymis. Co-treatment with exogenous PC resulted in significant improvement in intensity of histopathologic lesions, serum parameters, testosterone level, proinflammatory cytokines, and oxidative/antioxidative status. However, it does not affect the brain content of acetylcholine and acetylcholinesterase. Conclusively, treatment with exogenous PC can retrieve the adverse effect of aluminum toxicities through its antioxidative and anti-inflammatory properties.

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References

Beutler E, Duron O, Kelly B . Improved method for the determination of blood glutathione. J Lab Clin Med. 1963; 61:882-8. View

Ko M, Hattori T, Abdullah M, Gong J, Yamane T, Michikawa M . Phosphatidylcholine protects neurons from toxic effects of amyloid β-protein in culture. Brain Res. 2016; 1642:376-383. DOI: 10.1016/j.brainres.2016.04.035. View

Verstraeten S, Aimo L, Oteiza P . Aluminium and lead: molecular mechanisms of brain toxicity. Arch Toxicol. 2008; 82(11):789-802. DOI: 10.1007/s00204-008-0345-3. View

Nguyen N, Braley S, Fleming N, Lambourne L, Rivers R, Wolfe B . Comparison of postoperative hepatic function after laparoscopic versus open gastric bypass. Am J Surg. 2003; 186(1):40-4. DOI: 10.1016/s0002-9610(03)00106-5. View

Platt B, Fiddler G, Riedel G, Henderson Z . Aluminium toxicity in the rat brain: histochemical and immunocytochemical evidence. Brain Res Bull. 2001; 55(2):257-67. DOI: 10.1016/s0361-9230(01)00511-1. View

Anane R, Creppy E . Lipid peroxidation as pathway of aluminium cytotoxicity in human skin fibroblast cultures: prevention by superoxide dismutase+catalase and vitamins E and C. Hum Exp Toxicol. 2002; 20(9):477-81. DOI: 10.1191/096032701682693053. View

Qiu P, Cui X, Barochia A, Li Y, Natanson C, Eichacker P . The evolving experience with therapeutic TNF inhibition in sepsis: considering the potential influence of risk of death. Expert Opin Investig Drugs. 2011; 20(11):1555-64. PMC: 3523300. DOI: 10.1517/13543784.2011.623125. View

Guo C, Lin C, Yeh M, Hsu G . Aluminum-induced suppression of testosterone through nitric oxide production in male mice. Environ Toxicol Pharmacol. 2011; 19(1):33-40. DOI: 10.1016/j.etap.2004.02.009. View

Nehru B, Anand P . Oxidative damage following chronic aluminium exposure in adult and pup rat brains. J Trace Elem Med Biol. 2005; 19(2-3):203-8. DOI: 10.1016/j.jtemb.2005.09.004. View

10.

Chung S, Moriyama T, Uezu E, Uezu K, Hirata R, Yohena N . Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia. J Nutr. 1995; 125(6):1484-9. DOI: 10.1093/jn/125.6.1484. View

11.

Johnson V, Sharma R . Aluminum disrupts the pro-inflammatory cytokine/neurotrophin balance in primary brain rotation-mediated aggregate cultures: possible role in neurodegeneration. Neurotoxicology. 2003; 24(2):261-8. DOI: 10.1016/S0161-813X(02)00194-8. View

12.

Geyikoglu F, Turkez H, Bakir T, Cicek M . The genotoxic, hepatotoxic, nephrotoxic, haematotoxic and histopathological effects in rats after aluminium chronic intoxication. Toxicol Ind Health. 2012; 29(9):780-91. DOI: 10.1177/0748233712440140. View

13.

Blusztajn J, Zeisel S, Wurtman R . Synthesis of lecithin (phosphatidylcholine) from phosphatidylethanolamine in bovine brain. Brain Res. 1979; 179(2):319-27. DOI: 10.1016/0006-8993(79)90447-5. View

14.

Lee H, Kim B, Nam Y, Sohn U, Park E, Hong S . Protective role of phosphatidylcholine against cisplatin-induced renal toxicity and oxidative stress in rats. Food Chem Toxicol. 2013; 58:388-93. DOI: 10.1016/j.fct.2013.05.005. View

15.

Abdel-Moneim A . Effects of taurine against histomorphological and ultrastructural changes in the testes of mice exposed to aluminium chloride. Arh Hig Rada Toksikol. 2013; 64(3):405-14. DOI: 10.2478/10004-1254-64-2013-2322. View

16.

El-Demerdash F . Antioxidant effect of vitamin E and selenium on lipid peroxidation, enzyme activities and biochemical parameters in rats exposed to aluminium. J Trace Elem Med Biol. 2004; 18(1):113-21. DOI: 10.1016/j.jtemb.2004.04.001. View

17.

Proudfoot A . Aluminium and zinc phosphide poisoning. Clin Toxicol (Phila). 2009; 47(2):89-100. DOI: 10.1080/15563650802520675. View

18.

Jope R . Effects of phosphatidylcholine administration to rats on choline in blood and choline and acetylcholine in brain. J Pharmacol Exp Ther. 1982; 220(2):322-8. View

19.

Ochmanski W, Barabasz W . [Aluminum--occurrence and toxicity for organisms]. Przegl Lek. 2001; 57(11):665-8. View

20.

Akeson M, Munns D, Burau R . Adsorption of Al3+ to phosphatidylcholine vesicles. Biochim Biophys Acta. 1989; 986(1):33-40. DOI: 10.1016/0005-2736(89)90269-1. View