The Role of Transient Receptor Potential Vanilloid 4 in Pulmonary Inflammatory Diseases

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2017 May 20

PMID 28523001

Citations 27

Authors

Rachel G Scheraga

Brian D Southern

Lisa M Grove

Mitchell A Olman

Affiliations

Soon will be listed here.

Abstract

Ion channels/pumps are essential regulators of organ homeostasis and disease. In the present review, we discuss the role of the mechanosensitive cation channel, transient receptor potential vanilloid 4 (TRPV4), in cytokine secretion and pulmonary inflammatory diseases such as asthma, cystic fibrosis (CF), and acute lung injury/acute respiratory distress syndrome (ARDS). TRPV4 has been shown to play a role in lung diseases associated with lung parenchymal stretch or stiffness. TRPV4 indirectly mediates hypotonicity-induced smooth muscle contraction and airway remodeling in asthma. Further, the literature suggests that in CF TRPV4 may improve ciliary beat frequency enhancing mucociliary clearance, while at the same time increasing pro-inflammatory cytokine secretion/lung tissue injury. Currently it is understood that the role of TRPV4 in immune cell function and associated lung tissue injury/ARDS may depend on the injury stimulus. Uncovering the downstream mechanisms of TRPV4 action in pulmonary inflammatory diseases is likely important to understanding disease pathogenesis and may lead to novel therapeutics.

Citing Articles

Ion Channels in the Immune Response of Asthma.

Yan L, Zhang L, Ogunniyi K, Hong L J Respir Biol Transl Med. 2024; 1(4).

PMID: 39664985 PMC: 11633837. DOI: 10.70322/jrbtm.2024.10019.

TRPV4-A Multifunctional Cellular Sensor Protein with Therapeutic Potential.

Koskimaki S, Tojkander S Sensors (Basel). 2024; 24(21).

PMID: 39517820 PMC: 11548305. DOI: 10.3390/s24216923.

TRPV4 Activation during Guinea Pig Airway Smooth Muscle Contraction Promotes Ca and Na Influx.

Montano L, Carbajal-Garcia A, Casas-Hernandez M, Arredondo-Zamarripa D, Reyes-Garcia J Pharmaceuticals (Basel). 2024; 17(3).

PMID: 38543079 PMC: 10976253. DOI: 10.3390/ph17030293.

Mechanosensitive channels in lung disease.

Zheng M, Borkar N, Yao Y, Ye X, Vogel E, Pabelick C Front Physiol. 2023; 14:1302631.

PMID: 38033335 PMC: 10684786. DOI: 10.3389/fphys.2023.1302631.

Purinergic P2Y2 receptor-induced activation of endothelial TRPV4 channels mediates lung ischemia-reperfusion injury.

Kuppusamy M, Ta H, Davenport H, Bazaz A, Kulshrestha A, Daneva Z Sci Signal. 2023; 16(808):eadg1553.

PMID: 37874885 PMC: 10683978. DOI: 10.1126/scisignal.adg1553.

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