The Anticonvulsant Effects of Ketogenic Diet on Epileptic Seizures and Potential Mechanisms

Overview

Journal Curr Neuropharmacol

Publisher Bentham Science Publishers

Date 2017 May 20

PMID 28521671

Citations 22

Authors

Yifan Zhang

Jingwei Xu

Kun Zhang

Wei Yang

Bingjin Li

Affiliations

Soon will be listed here.

Abstract

Background: Epilepsy is a syndrome of brain dysfunction induced by the aberrant excitability of certain neurons. Despite advances in surgical technique and anti-epileptic drug in recent years, recurrent epileptic seizures remain intractable and lead to a serious morbidity in the world. The ketogenic diet refers to a high-fat, low-carbohydrate and adequate-protein diet. Currently, its beneficial effects on epileptic seizure reduction have been well established. However, the detailed mechanisms underlying the anti-epileptic effects of ketogenic diet are still poorly understood. In this article, the possible roles of ketogenic diet on epilepsy were discussed.

Methods: Data was obtained from the websites including Web of Science, Medline, Pubmed, Scopus, based on these keywords: "Ketogenic diet" and "epilepsy".

Results: As shown in both clinical and basic studies, the therapeutic effects of ketogenic diet might involve neuronal metabolism, neurotransmitter function, neuronal membrane potential and neuron protection against ROS.

Conclusion: In this review, we systematically reviewed the effects and possible mechanisms of ketogenic diet on epilepsy, which may optimize the therapeutic strategies against epilepsy.

Citing Articles

Impact of the Ketogenic Diet on Neurological Diseases: A Review.

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Ketogenic diet as a therapeutic approach in autism spectrum disorder: a narrative review.

Ozturk E, Aslan Cin N, Cansu A, Akyol A Metab Brain Dis. 2024; 40(1):67.

PMID: 39692905 DOI: 10.1007/s11011-024-01506-5.

Ketogenic Diet and Neuroinflammation: Implications for Neuroimmunometabolism and Therapeutic Approaches to Refractory Epilepsy.

Guerreiro D, Almeida A, Ramalho R Nutrients. 2024; 16(23).

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Long-term follow-up of nutritional status in children with GLUT1 Deficiency Syndrome treated with classic ketogenic diet: a 5-year prospective study.

De Amicis R, Leone A, Pellizzari M, Foppiani A, Battezzati A, Lessa C Front Nutr. 2023; 10:1148960.

PMID: 37293674 PMC: 10244766. DOI: 10.3389/fnut.2023.1148960.

ROS-removing nano-medicine for navigating inflammatory microenvironment to enhance anti-epileptic therapy.

Zhou Z, Li K, Chu Y, Li C, Zhang T, Liu P Acta Pharm Sin B. 2023; 13(3):1246-1261.

PMID: 36970212 PMC: 10031259. DOI: 10.1016/j.apsb.2022.09.019.

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