Body Mass Index As a Classifier to Predict Biochemical Recurrence After Radical Prostatectomy in Patients with Lower Prostate-specific Antigen Levels

Overview

Journal Mol Clin Oncol

Specialty Oncology

Date 2017 May 19

PMID 28515927

Citations 2

Authors

Keisuke Goto

Hirotaka Nagamatsu

Jun Teishima

Yuki Kohada

Shinsuke Fujii

Yoshimasa Kurimura

Koji Mita

Masanobu Shigeta

Satoshi Maruyama

Yoji Inoue

Mitsuru Nakahara

Akio Matsubara

Affiliations

Soon will be listed here.

Abstract

Prostate cancer, one of the most common malignant tumors among men, is closely associated with obesity and, thus far, several studies have suggested the association between obesity and aggressive pathological characteristics in the United States. However, the effect of obesity on prostate cancer mortality is controversial, and it remains unclear whether obesity contributes to the aggressiveness of prostate cancer in Asian patients. The aim of the present study was to investigate the association between body mass index (BMI) and the clinicopathological characteristics of prostate cancer in 2,003 Japanese patients who underwent radical prostatectomy. There was a significant association between higher BMI and higher Gleason score (GS). The multivariate analysis also revealed that BMI was an independent indicator for GS ≥8 at surgery. Moreover, among patients with lower prostate-specific antigen levels, biochemical recurrence-free survival was significantly worse in those with higher BMI. These results suggest that BMI may be a classifier for predicting adverse pathological findings and biochemical recurrence after radical prostatectomy in Japanese patients.

Citing Articles

Obesity and biochemical recurrence in clinically localised prostate cancer: a systematic review and meta-analysis of 86,490 patients.

Rivera-Izquierdo M, Perez de Rojas J, Martinez-Ruiz V, Arrabal-Polo M, Perez-Gomez B, Jimenez-Moleon J Prostate Cancer Prostatic Dis. 2022; 25(3):411-421.

PMID: 34987170 DOI: 10.1038/s41391-021-00481-7.

Effect of obesity on the prognosis and recurrence of prostate cancer after radical prostatectomy: a meta-analysis.

Luo R, Chen Y, Ran K, Jiang Q Transl Androl Urol. 2021; 9(6):2713-2722.

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References

Epstein J, Egevad L, Amin M, Delahunt B, Srigley J, Humphrey P . The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System. Am J Surg Pathol. 2015; 40(2):244-52. DOI: 10.1097/PAS.0000000000000530. View

Calle E, Rodriguez C, Walker-Thurmond K, Thun M . Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003; 348(17):1625-38. DOI: 10.1056/NEJMoa021423. View

Buschemeyer 3rd W, Freedland S . Obesity and prostate cancer: epidemiology and clinical implications. Eur Urol. 2007; 52(2):331-43. DOI: 10.1016/j.eururo.2007.04.069. View

Salomon L, Levrel O, De La Taille A, Anastasiadis A, Saint F, Zaki S . Radical prostatectomy by the retropubic, perineal and laparoscopic approach: 12 years of experience in one center. Eur Urol. 2002; 42(2):104-10; discussion 110-1. DOI: 10.1016/s0302-2838(02)00263-4. View

Freedland S, Aronson W, Kane C, Presti Jr J, Amling C, Elashoff D . Impact of obesity on biochemical control after radical prostatectomy for clinically localized prostate cancer: a report by the Shared Equal Access Regional Cancer Hospital database study group. J Clin Oncol. 2003; 22(3):446-53. DOI: 10.1200/JCO.2004.04.181. View

Bai P, Hu M, Xu H, Zhu W, Hu J, Yang T . Body mass index is associated with higher Gleason score and biochemical recurrence risk following radical prostatectomy in Chinese men: a retrospective cohort study and meta-analysis. World J Surg Oncol. 2015; 13:311. PMC: 4635546. DOI: 10.1186/s12957-015-0725-0. View

Komaru A, Kamiya N, Suzuki H, Endo T, Takano M, Yano M . Implications of body mass index in Japanese patients with prostate cancer who had undergone radical prostatectomy. Jpn J Clin Oncol. 2010; 40(4):353-9. DOI: 10.1093/jjco/hyp164. View

Dunn J . Cancer epidemiology in populations of the United States--with emphasis on Hawaii and California--and Japan. Cancer Res. 1975; 35(11 Pt. 2):3240-5. View

Grubb 3rd R, Black A, Izmirlian G, Hickey T, Pinsky P, Mabie J . Serum prostate-specific antigen hemodilution among obese men undergoing screening in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Cancer Epidemiol Biomarkers Prev. 2009; 18(3):748-51. DOI: 10.1158/1055-9965.EPI-08-0938. View

10.

Giovannucci E, Rimm E, Liu Y, Leitzmann M, Wu K, Stampfer M . Body mass index and risk of prostate cancer in U.S. health professionals. J Natl Cancer Inst. 2003; 95(16):1240-4. DOI: 10.1093/jnci/djg009. View

11.

Freedland S, Isaacs W, Mangold L, Yiu S, Grubb K, Partin A . Stronger association between obesity and biochemical progression after radical prostatectomy among men treated in the last 10 years. Clin Cancer Res. 2005; 11(8):2883-8. DOI: 10.1158/1078-0432.CCR-04-2257. View

12.

Freedland S, Grubb K, Yiu S, Humphreys E, Nielsen M, Mangold L . Obesity and risk of biochemical progression following radical prostatectomy at a tertiary care referral center. J Urol. 2005; 174(3):919-22. DOI: 10.1097/01.ju.0000169459.78982.d7. View

13.

Andersson S, Wolk A, Bergstrom R, Adami H, Engholm G, Englund A . Body size and prostate cancer: a 20-year follow-up study among 135006 Swedish construction workers. J Natl Cancer Inst. 1997; 89(5):385-9. DOI: 10.1093/jnci/89.5.385. View

14.

Amling C, Riffenburgh R, Sun L, Moul J, Lance R, Kusuda L . Pathologic variables and recurrence rates as related to obesity and race in men with prostate cancer undergoing radical prostatectomy. J Clin Oncol. 2003; 22(3):439-45. DOI: 10.1200/JCO.2004.03.132. View

15.

Shimizu H, Ross R, Bernstein L, Yatani R, Henderson B, Mack T . Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County. Br J Cancer. 1991; 63(6):963-6. PMC: 1972548. DOI: 10.1038/bjc.1991.210. View

16.

Freedland S, Terris M, Presti Jr J, Amling C, Kane C, Trock B . Obesity and biochemical outcome following radical prostatectomy for organ confined disease with negative surgical margins. J Urol. 2004; 172(2):520-4. DOI: 10.1097/01.ju.0000135302.58378.ae. View

17.

Baillargeon J, Pollock B, Kristal A, Bradshaw P, Hernandez J, Basler J . The association of body mass index and prostate-specific antigen in a population-based study. Cancer. 2005; 103(5):1092-5. DOI: 10.1002/cncr.20856. View

18.

Narita S, Mitsuzuka K, Yoneyama T, Tsuchiya N, Koie T, Kakoi N . Impact of body mass index on clinicopathological outcome and biochemical recurrence after radical prostatectomy. Prostate Cancer Prostatic Dis. 2013; 16(3):271-6. DOI: 10.1038/pcan.2013.16. View

19.

Lee S, Lee W, Jeong M, Abdullajanov M, Kim D, Park H . Is body mass index associated with pathological outcomes after radical prostatectomy in Korean men?. BJU Int. 2010; 107(8):1250-5. DOI: 10.1111/j.1464-410X.2010.09592.x. View

20.

Rodriguez C, Patel A, Calle E, Jacobs E, Chao A, Thun M . Body mass index, height, and prostate cancer mortality in two large cohorts of adult men in the United States. Cancer Epidemiol Biomarkers Prev. 2001; 10(4):345-53. View