The Interplay Between Oncogenic Signaling Networks and Mitochondrial Dynamics

Overview

Journal Antioxidants (Basel)

Date 2017 May 18

PMID 28513539

Citations 21

Authors

Sarbajeet Nagdas

David F Kashatus

Affiliations

Soon will be listed here.

Abstract

Mitochondria are dynamic organelles that alter their organization in response to a variety of cellular cues. Mitochondria are central in many biologic processes, such as cellular bioenergetics and apoptosis, and mitochondrial network morphology can contribute to those physiologic processes. Some of the biologic processes that are in part governed by mitochondria are also commonly deregulated in cancers. Furthermore, patient tumor samples from a variety of cancers have revealed that mitochondrial dynamics machinery may be deregulated in tumors. In this review, we will discuss how commonly mutated oncogenes and their downstream effector pathways regulate the mitochondrial dynamics machinery to promote changes in mitochondrial morphology as well as the physiologic consequences of altered mitochondrial morphology for tumorigenic growth.

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