Inhibitory Effect of Chemical Constituents Isolated from on Polyol Pathway and Simultaneous Quantification of Major Bioactive Compounds

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2017 May 18

PMID 28512639

Citations 9

Authors

Yoon Kyoung Lee

Eun Young Hong

Wan Kyunn Whang

Affiliations

Soon will be listed here.

Abstract

Blocking the polyol pathway plays an important role preventing diabetic complications. Therefore, aldose reductase (AR) and advanced glycation endproducts (AGEs) formation has significant effect on diabetic complications. has long been used as treatment of various diseases in Korea. However, no literatures have reported on AR and AGEs formation inhibitory activities of . For these reasons, we aimed to assess that had potential as anti-diabetic complications agents. We led to isolation of two coumarins ( and ), nine flavonoids (-), five caffeoylquinic acids (-), three diterpene glycosides (-), and one phenolic compound () from . Among them, hispidulin (), 6-methoxytricin (), arteanoflavone (), quercetin-3-gentiobioside (), 1,3-di--caffeoylquinic acid (), and suavioside A () were first reported on the isolation from . Not only two coumarins ( and ), nine flavonoids (-), and five caffeoylquinic acids (-) but also extracts showed significant inhibitor on AR and AGEs formation activities. We analyzed contents of major bioactive compounds in Korea's various regions of . Overall, we selected Yangyang, Gangwon-do, from June, which contained the highest amounts of bioactive compounds, as suitable areas for cultivating as preventive or therapeutic agent in the treatment of diabetic complications.

Citing Articles

spp.: An Update on Its Chemical Composition, Pharmacological and Toxicological Profiles.

Sharifi-Rad J, Herrera-Bravo J, Semwal P, Painuli S, Badoni H, Ezzat S Oxid Med Cell Longev. 2022; 2022:5628601.

PMID: 36105486 PMC: 9467740. DOI: 10.1155/2022/5628601.

Chemical Structure and Biological Activities of Secondary Metabolites from L.

Kim S, Lee E, Hillman P, Ko J, Yang I, Nam S Molecules. 2021; 26(8).

PMID: 33924656 PMC: 8069253. DOI: 10.3390/molecules26082252.

Bioassay-Guided Isolation of Anti-Alzheimer Active Components from the Aerial Parts of and Simultaneous Analysis for Marker Compounds.

Park J, Whang W Molecules. 2020; 25(24).

PMID: 33322478 PMC: 7764330. DOI: 10.3390/molecules25245867.

A New Oleanane Type Saponin from the Aerial Parts of with Anti-Oxidant and Anti-Diabetic Potential.

Parveen A, Farooq M, Kyunn W Molecules. 2020; 25(9).

PMID: 32384790 PMC: 7248923. DOI: 10.3390/molecules25092171.

(Dowijigi) inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppressing the NF-κB signaling pathway.

Kim S, Vetrivel P, Kim H, Ha S, Gowda Saralamma V, Kim G Exp Ther Med. 2020; 19(3):2161-2170.

PMID: 32104280 PMC: 7027351. DOI: 10.3892/etm.2020.8472.

References

Jung H, Park J, Islam M, Jin S, Min B, Lee J . Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation. Arch Pharm Res. 2012; 35(6):1021-35. DOI: 10.1007/s12272-012-0610-0. View

Pan R, Dai Y, Gao X, Xia Y . Scopolin isolated from Erycibe obtusifolia Benth stems suppresses adjuvant-induced rat arthritis by inhibiting inflammation and angiogenesis. Int Immunopharmacol. 2009; 9(7-8):859-69. DOI: 10.1016/j.intimp.2009.02.019. View

Hwang J, Ji H, Koo K, Lee N, Yeo H, Cheong S . AIP1, a water-soluble fraction from Artemisia iwayomogi, suppresses thymocyte apoptosis in vitro and down-regulates the expression of Fas gene. Biol Pharm Bull. 2005; 28(5):921-4. DOI: 10.1248/bpb.28.921. View

Kim S, Lee C, Kang S, Jung H, Choi J . Chlorogenic acid, an antioxidant principle from the aerial parts ofArtemisia iwayomogi that acts on 1,1-diphenyl-2-picrylhydrazyl radical. Arch Pharm Res. 1997; 20(2):148-54. DOI: 10.1007/BF02974002. View

Kawanishi K, Ueda H, Moriyasu M . Aldose reductase inhibitors from the nature. Curr Med Chem. 2003; 10(15):1353-74. DOI: 10.2174/0929867033457304. View

Saraswat M, Muthenna P, Suryanarayana P, Petrash J, Reddy G . Dietary sources of aldose reductase inhibitors: prospects for alleviating diabetic complications. Asia Pac J Clin Nutr. 2008; 17(4):558-65. View

Lee J, Sung H, Jeon C, Gill B, Oh G, Youn H . A carbohydrate fraction, AIP1 from Artemisia iwayomogi suppresses pulmonary eosinophilia and Th2-type cytokine production in an ovalbumin-induced allergic asthma. Down-regulation of TNF-alpha expression in the lung. Int Immunopharmacol. 2007; 8(1):117-25. DOI: 10.1016/j.intimp.2007.10.022. View

COLLINS J, CORDER C . Aldose reductase and sorbitol dehydrogenase distribution in substructures of normal and diabetic rat lens. Invest Ophthalmol Vis Sci. 1977; 16(3):242-3. View

Sato S, Kador P . Inhibition of aldehyde reductase by aldose reductase inhibitors. Biochem Pharmacol. 1990; 40(5):1033-42. DOI: 10.1016/0006-2952(90)90490-c. View

10.

Ji H, Yeo H, Lee N, Hwang J, Koo K, Cheong S . A carbohydrate fraction, AIP1, from Artemisia iwayomogi down-regulates Fas gene expression and suppresses apoptotic death of the thymocytes induced by 2,3,7,8-tectrachlorodibenzo-p-dioxin. Biotechnol Lett. 2005; 27(4):253-7. DOI: 10.1007/s10529-004-8294-2. View

11.

Lee S, Ding Y, Yan X, Kim Y, Jang H . Scopoletin and scopolin isolated from Artemisia iwayomogi suppress differentiation of osteoclastic macrophage RAW 264.7 cells by scavenging reactive oxygen species. J Nat Prod. 2013; 76(4):615-20. DOI: 10.1021/np300824h. View

12.

Kato A, Yasuko H, Goto H, Hollinshead J, Nash R, Adachi I . Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity. Phytomedicine. 2007; 16(2-3):258-61. DOI: 10.1016/j.phymed.2007.04.008. View

13.

Ryu J, Ahn H, Kim J, Kim Y . Inhibitory activity of plant extracts on nitric oxide synthesis in LPS-activated macrophages. Phytother Res. 2003; 17(5):485-9. DOI: 10.1002/ptr.1180. View

14.

Lim S, Jung S, Ji J, Shin K, Keum S . Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. J Pharm Pharmacol. 2001; 53(5):653-68. DOI: 10.1211/0022357011775983. View

15.

Sasaki N, Fukatsu R, Tsuzuki K, Hayashi Y, Yoshida T, Fujii N . Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases. Am J Pathol. 1998; 153(4):1149-55. PMC: 1853056. DOI: 10.1016/S0002-9440(10)65659-3. View

16.

Chen J, Mangelinckx S, Ma L, Wang Z, Li W, De Kimpe N . Caffeoylquinic acid derivatives isolated from the aerial parts of Gynura divaricata and their yeast α-glucosidase and PTP1B inhibitory activity. Fitoterapia. 2014; 99:1-6. DOI: 10.1016/j.fitote.2014.08.015. View

17.

Miyamae Y, Kurisu M, Han J, Isoda H, Shigemori H . Structure-activity relationship of caffeoylquinic acids on the accelerating activity on ATP production. Chem Pharm Bull (Tokyo). 2011; 59(4):502-7. DOI: 10.1248/cpb.59.502. View

18.

Jung H, Kim Y, Choi J . Quantitative HPLC analysis of two key flavonoids and inhibitory activities against aldose reductase from different parts of the Korean thistle, Cirsium maackii. Food Chem Toxicol. 2009; 47(11):2790-7. DOI: 10.1016/j.fct.2009.08.014. View

19.

Sun Y, Ma X, Liu J . [Compounds from fraction with cardiovascular activity of Chrysanthemum indicum]. Zhongguo Zhong Yao Za Zhi. 2012; 37(1):61-5. View

20.

Lee Y, Kang Y, Jung J, Kang I, Han S, Chung J . Inhibitory constituents of aldose reductase in the fruiting body of Phellinus linteus. Biol Pharm Bull. 2008; 31(4):765-8. DOI: 10.1248/bpb.31.765. View