An Assessment of Osteoporotic Conditions Among Users and Non-Users of Warfarin: A Case-Control Study

Overview

Journal J Clin Diagn Res

Specialty General Medicine

Date 2017 May 18

PMID 28511429

Citations 2

Authors

Aseel Hadi Abdulameer

Syed Azhar Bin Syed Sulaiman

Muhamad Bin Sk Abdul Kader

Affiliations

Soon will be listed here.

Abstract

Introduction: Warfarin is an oral anticoagulant which is associated with a decrease in Bone Mass Density (BMD).

Aim: The study aimed to explore the prevalence of osteoporosis conditions in Malaysians with chronic warfarin patients using calcaneal quarter of Quantitative Ultrasound (QUS) machine and to investigate whether long-term sodium warfarin therapy that antagonizes vitamin K is affecting the increasing rate of osteoporosis in Penang and to find the risk factors of getting osteoporosis among warfarin users and its non users.

Materials And Methods: A case-control study was conducted among 130 patients using warfarin, attending the outpatient clinic at Hospital Pulau Pinang. A convenience sampling method was used to recruit the required sample. Another 140 subjects were selected from the community as a control group (non-users of warfarin).

Results: This study showed that more than three-quarter patients (82%) were at high risk of abnormal BMD. The warfarin users were two times more likely to have a higher osteoporosis risk compared to control group. Moreover, BMD has a negative correlation with age, but has a positive correlation with Body Mass Index (BMI). Patients showed a negative correlation with a higher dose of warfarin intake.

Conclusion: This study concluded that osteopenia and osteoporosis are serious problems between users and non-users warfarin in Penang. Therefore, it should be taken into consideration in the Malaysian Health Ministry's agenda.

Citing Articles

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PMID: 35453723 PMC: 9030599. DOI: 10.3390/biology11040524.

Vitamin K‑dependent proteins involved in bone and cardiovascular health (Review).

Wen L, Chen J, Duan L, Li S Mol Med Rep. 2018; 18(1):3-15.

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