DFmr1 Plays Roles in Small RNA Pathways of Drosophila Melanogaster

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2017 May 17

PMID 28509881

Citations 10

Authors

Valeria Specchia

Simona DAttis

Antonietta Puricella

Maria Pia Bozzetti

Affiliations

Soon will be listed here.

Abstract

Fragile-X syndrome is the most common form of inherited mental retardation accompanied by other phenotypes, including macroorchidism. The disorder originates with mutations in the gene coding for the FMRP protein, which, with its paralogs and , constitute a well-conserved family of RNA-binding proteins. is a good model for the syndrome because it has a unique gene: . Recently, in addition to its confirmed role in the miRNA pathway, a function for dFmr1 in the piRNA pathway, operating in gonads, has been established. In this review we report a summary of the piRNA pathways occurring in gonads with a special emphasis on the relationship between the genes and the system; we also analyze the roles of dFmr1 in the gonads, exploring their genetic and biochemical interactions to reveal some unexpected connections.

Citing Articles

Expression of Transposable Elements in the Brain of the Model for Fragile X Syndrome.

De Donno M, Puricella A, DAttis S, Specchia V, Bozzetti M Genes (Basel). 2023; 14(5).

PMID: 37239420 PMC: 10218032. DOI: 10.3390/genes14051060.

as a Model to Study Fragile X-Associated Disorders.

Trajkovic J, Makevic V, Pesic M, Pavkovic-Lucic S, Milojevic S, Cvjetkovic S Genes (Basel). 2023; 14(1).

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The Genome Lacks the - System.

De Grassi A, Tritto P, Palumbo V, Bozzetti M, Berloco M Cells. 2022; 11(23).

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Identification of GOLPH3 Partners in Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders.

Sechi S, Karimpour-Ghahnavieh A, Frappaolo A, Di Francesco L, Piergentili R, Schinina E Cells. 2021; 10(9).

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Targeted whole exome sequencing and Drosophila modelling to unveil the molecular basis of primary ovarian insufficiency.

Bestetti I, Barbieri C, Sironi A, Specchia V, Yatsenko S, De Donno M Hum Reprod. 2021; 36(11):2975-2991.

PMID: 34480478 PMC: 8523209. DOI: 10.1093/humrep/deab192.

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