MicroRNAs in Dysfunctional Adipose Tissue: Cardiovascular Implications

Overview

Journal Cardiovasc Res

Specialty Cardiology & Vascular Diseases

Date 2017 May 16

PMID 28505257

Citations 20

Authors

Basak Icli

Mark W Feinberg

Affiliations

Soon will be listed here.

Abstract

In this review, we focus on the emerging role of microRNAs, non-coding RNAs that regulate gene expression and signaling pathways, in dysfunctional adipose tissue. We highlight current paradigms of microRNAs involved in adipose differentiation and function in depots such as white, brown, and beige adipose tissues and potential implications of microRNA dysregulation in human disease such as obesity, inflammation, microvasculature dysfunction, and related cardiovascular diseases. We highlight accumulating studies indicating that adipocyte-derived microRNAs may not only serve as biomarkers of cardiometabolic disease, but also may directly regulate gene expression of other tissues. Finally, we discuss the future prospects, challenges, and emerging strategies for microRNA delivery and targeting for therapeutic applications in cardiovascular disease states associated with adipocyte dysfunction.

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