Structure and Function of Histone Acetyltransferase MOF

Overview

Journal AIMS Biophys

Specialty Biophysics

Date 2017 May 16

PMID 28503659

Citations 7

Authors

Qiao Yi Chen

Max Costa

Hong Sun

Affiliations

Soon will be listed here.

Abstract

MOF was first identified in as an important component of the dosage compensation complex. As a member of MYST family of histone acetyltransferase, MOF specifically deposits the acetyl groups to histone H4 lysine 16. Throughout evolution, MOF and its mammalian ortholog have retained highly conserved substrate specificity and similar enzymatic activities. MOF plays important roles in dosage compensation, ESC self-renewal, DNA damage and repair, cell survival, and gene expression regulation. Dysregulation of MOF has been implicated in tumor formation and progression of many types of human cancers. This review will discuss the structure and activity of mammalian hMOF as well as its function in H4K16 acetylation, DNA damage response, stem cell pluripotency, and carcinogenesis.

Citing Articles

Stabilization of MOF (KAT8) by USP10 promotes esophageal squamous cell carcinoma proliferation and metastasis through epigenetic activation of ANXA2/Wnt signaling.

Li P, Yang L, Park S, Liu F, Li A, Zhu Y Oncogene. 2024; 43(12):899-917.

PMID: 38317006 DOI: 10.1038/s41388-024-02955-z.

BAZ1B the Protean Protein.

Sharif S, Zamani N, Chadwick B Genes (Basel). 2021; 12(10).

PMID: 34680936 PMC: 8536118. DOI: 10.3390/genes12101541.

The Contribution of Histone Crotonylation to Tissue Health and Disease: Focus on Kidney Health.

Martinez-Moreno J, Fontecha-Barriuso M, Martin-Sanchez D, Sanchez-Nino M, Ruiz-Ortega M, Sanz A Front Pharmacol. 2020; 11:393.

PMID: 32308622 PMC: 7145939. DOI: 10.3389/fphar.2020.00393.

Molecular and epigenetic mechanisms of Cr(VI)-induced carcinogenesis.

Chen Q, Murphy A, Sun H, Costa M Toxicol Appl Pharmacol. 2019; 377:114636.

PMID: 31228494 PMC: 6658109. DOI: 10.1016/j.taap.2019.114636.

Corn dried distillers grains with solubles (cDDGS) in the diet of pigs change the expression of adipose genes that are potential therapeutic targets in metabolic and cardiovascular diseases.

Oczkowicz M, Szmatola T, Swiatkiewicz M, Pawlina-Tyszko K, Gurgul A, Zabek T BMC Genomics. 2018; 19(1):864.

PMID: 30509175 PMC: 6276254. DOI: 10.1186/s12864-018-5265-x.

References

Rea S, Xouri G, Akhtar A . Males absent on the first (MOF): from flies to humans. Oncogene. 2007; 26(37):5385-94. DOI: 10.1038/sj.onc.1210607. View

Sulli G, Di Micco R, dAdda di Fagagna F . Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer. Nat Rev Cancer. 2012; 12(10):709-20. DOI: 10.1038/nrc3344. View

Mizushima N, Levine B, Cuervo A, Klionsky D . Autophagy fights disease through cellular self-digestion. Nature. 2008; 451(7182):1069-75. PMC: 2670399. DOI: 10.1038/nature06639. View

Brockdorff N, Turner B . Dosage compensation in mammals. Cold Spring Harb Perspect Biol. 2015; 7(3):a019406. PMC: 4355265. DOI: 10.1101/cshperspect.a019406. View

Yuan H, Rossetto D, Mellert H, Dang W, Srinivasan M, Johnson J . MYST protein acetyltransferase activity requires active site lysine autoacetylation. EMBO J. 2011; 31(1):58-70. PMC: 3252582. DOI: 10.1038/emboj.2011.382. View

Shogren-Knaak M, Ishii H, Sun J, Pazin M, Davie J, Peterson C . Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science. 2006; 311(5762):844-7. DOI: 10.1126/science.1124000. View

Buscaino A, Kocher T, Kind J, Holz H, Taipale M, Wagner K . MOF-regulated acetylation of MSL-3 in the Drosophila dosage compensation complex. Mol Cell. 2003; 11(5):1265-77. DOI: 10.1016/s1097-2765(03)00140-0. View

Nielsen P, Nietlispach D, Buscaino A, Warner R, Akhtar A, Murzin A . Structure of the chromo barrel domain from the MOF acetyltransferase. J Biol Chem. 2005; 280(37):32326-31. DOI: 10.1074/jbc.M501347200. View

Wang Z, Zang C, Cui K, Schones D, Barski A, Peng W . Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell. 2009; 138(5):1019-31. PMC: 2750862. DOI: 10.1016/j.cell.2009.06.049. View

10.

Pfister S, Rea S, Taipale M, Mendrzyk F, Straub B, Ittrich C . The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma. Int J Cancer. 2007; 122(6):1207-13. DOI: 10.1002/ijc.23283. View

11.

Levine A . p53, the cellular gatekeeper for growth and division. Cell. 1997; 88(3):323-31. DOI: 10.1016/s0092-8674(00)81871-1. View

12.

Fraga M, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G . Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet. 2005; 37(4):391-400. DOI: 10.1038/ng1531. View

13.

Gupta A, Sharma G, Young C, Agarwal M, Smith E, Paull T . Involvement of human MOF in ATM function. Mol Cell Biol. 2005; 25(12):5292-305. PMC: 1140595. DOI: 10.1128/MCB.25.12.5292-5305.2005. View

14.

Jenuwein T, Allis C . Translating the histone code. Science. 2001; 293(5532):1074-80. DOI: 10.1126/science.1063127. View

15.

Avvakumov N, Cote J . Functions of myst family histone acetyltransferases and their link to disease. Subcell Biochem. 2007; 41:295-317. View

16.

Keller C, Akhtar A . The MSL complex: juggling RNA-protein interactions for dosage compensation and beyond. Curr Opin Genet Dev. 2015; 31:1-11. DOI: 10.1016/j.gde.2015.03.007. View

17.

Smith E, Allis C, Lucchesi J . Linking global histone acetylation to the transcription enhancement of X-chromosomal genes in Drosophila males. J Biol Chem. 2001; 276(34):31483-6. DOI: 10.1074/jbc.C100351200. View

18.

Levine B, Kroemer G . Autophagy in the pathogenesis of disease. Cell. 2008; 132(1):27-42. PMC: 2696814. DOI: 10.1016/j.cell.2007.12.018. View

19.

Neal K, Pannuti A, Smith E, Lucchesi J . A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF. Biochim Biophys Acta. 2000; 1490(1-2):170-4. DOI: 10.1016/s0167-4781(99)00211-0. View

20.

Mellert H, McMahon S . hMOF, a KAT(8) with many lives. Mol Cell. 2009; 36(2):174-5. DOI: 10.1016/j.molcel.2009.10.005. View