Human As the Ultimate Wound Healing Model: Strategies for Studies Investigating the Dermal Lipidome

Overview

Journal Curr Dermatol Rep

Specialty Dermatology

Date 2017 May 16

PMID 28503364

Citations 3

Authors

Dayanjan S Wijesinghe

Urszula Osinska Warncke

Robert F Diegelmann

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Educate the reader of the multiple roles undertaken by the human epidermal lipidome and the experimental techniques of measuring them.

Recent Findings: Damage to skin elicits a wound healing process that is capped by the recreation of the lipid barrier. In addition to barrier function, lipids also undertake an active signaling role during wound healing. Achievement of these multiple functions necessitates a significant complexity and diversity in the lipidome resulting in a composition that is unique to the human skin. As such, any attempts to delineate the function of the lipidome during the wound healing process in humans need to be addressed via studies undertaken in humans.

Summary: The human cutaneous lipidome is unique and play a functionally significant role in maintaining barrier and regulating wound healing. Modern mass spectrometry and Raman spectroscopy based methods enable the investigation epidermal lipidome with respect to those functions.

Citing Articles

Multifaceted roles of mitochondria in wound healing and chronic wound pathogenesis.

Hunt M, Torres M, Bachar-Wikstrom E, Wikstrom J Front Cell Dev Biol. 2023; 11:1252318.

PMID: 37771375 PMC: 10523588. DOI: 10.3389/fcell.2023.1252318.

The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A coordinates acute wound healing and repair.

Macknight H, Stephenson D, Hoeferlin L, Benusa S, deLigio J, Maus K Sci Signal. 2019; 12(610).

PMID: 31796632 PMC: 8103357. DOI: 10.1126/scisignal.aav5918.

Multimodal, in Situ Imaging of Ex Vivo Human Skin Reveals Decrease of Cholesterol Sulfate in the Neoepithelium during Acute Wound Healing.

Castellanos A, Hernandez M, Tomic-Canic M, Jozic I, Fernandez-Lima F Anal Chem. 2019; 92(1):1386-1394.

PMID: 31789498 PMC: 8341291. DOI: 10.1021/acs.analchem.9b04542.

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