Hepatic Uptake of Conjugated Bile Acids is Mediated by Both Sodium Taurocholate Cotransporting Polypeptide and Organic Anion Transporting Polypeptides and Modulated by Intestinal Sensing of Plasma Bile Acid Levels in Mice

Overview

Journal Hepatology

Specialty Gastroenterology

Date 2017 May 13

PMID 28498614

Citations 62

Authors

Davor Slijepcevic

Reinout L P Roscam Abbing

Takeshi Katafuchi

Antje Blank

Joanne M Donkers

Stephanie van Hoppe

Dirk R de Waart

Dagmar Tolenaars

Jonathan H M van der Meer

Manon Wildenberg

Ulrich Beuers

Ronald P J Oude Elferink

Alfred H Schinkel

Stan F J van de Graaf

Affiliations

Soon will be listed here.

Abstract

Conclusion: NTCP and OATPs contribute to hepatic uptake of conjugated bile acids in mice, whereas the predominant uptake in humans is NTCP mediated. Enterocytes sense highly elevated levels of (conjugated) bile acids in the systemic circulation to induce FGF15/19, which modulates hepatic bile acid synthesis and uptake. (Hepatology 2017;66:1631-1643).

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