Racial/ethnic Disparities in Environmental Endocrine Disrupting Chemicals and Women's Reproductive Health Outcomes: Epidemiological Examples Across the Life Course

Overview

Journal Curr Epidemiol Rep

Specialty Public Health

Date 2017 May 13

PMID 28497013

Citations 87

Authors

Tamarra M James-Todd

Yu-Han Chiu

Ami R Zota

Affiliations

Soon will be listed here.

Abstract

Disparities in women's reproductive health outcomes across the life course have been well-documented. Endocrine disrupting chemicals may be one factor driving disparities, as studies suggest exposure to certain environmental endocrine disrupting chemicals, such as certain phthalates, bisphenol A, parabens and polybrominated diphenyl ethers are higher in non-whites. Yet, a limited amount of research has focused on these chemical exposures as a potential mediator of racial/ethnic differences in women's reproductive health outcomes, such as pubertal development, fibroids, infertility, and pregnancy complications. Given that race/ethnicity is a social construct, the purpose of this review was to present the current state of the literature on racial/ethnic disparities in both environmental endocrine disrupting chemicals, as well as associations between these chemicals and selected women's reproductive health outcomes. Our goal was to evaluate literature from populations based in the United States to: 1) characterize racial/ethnic differences in environmental endocrine disrupting chemicals and 2) systematically review literature on environmental endocrine disrupting chemicals and selected women's health outcomes in populations containing more than one racial/ethnic group. This review highlights the need for future work in determining whether higher exposures to some environmental endocrine disrupting chemicals might partly explain differences in women's reproductive health outcomes in these higher-exposure and high-risk groups.

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References

Koniecki D, Wang R, Moody R, Zhu J . Phthalates in cosmetic and personal care products: concentrations and possible dermal exposure. Environ Res. 2011; 111(3):329-36. DOI: 10.1016/j.envres.2011.01.013. View

Werner E, Braun J, Yolton K, Khoury J, Lanphear B . The association between maternal urinary phthalate concentrations and blood pressure in pregnancy: The HOME Study. Environ Health. 2015; 14:75. PMC: 4574131. DOI: 10.1186/s12940-015-0062-3. View

Fujimoto V, Kim D, Vom Saal F, Lamb J, Taylor J, Bloom M . Serum unconjugated bisphenol A concentrations in women may adversely influence oocyte quality during in vitro fertilization. Fertil Steril. 2010; 95(5):1816-9. DOI: 10.1016/j.fertnstert.2010.11.008. View

Dominguez T . Race, racism, and racial disparities in adverse birth outcomes. Clin Obstet Gynecol. 2008; 51(2):360-70. DOI: 10.1097/GRF.0b013e31816f28de. View

Robledo C, Peck J, Stoner J, Carabin H, Cowan L, Koch H . Is bisphenol-A exposure during pregnancy associated with blood glucose levels or diagnosis of gestational diabetes?. J Toxicol Environ Health A. 2013; 76(14):865-73. PMC: 3801171. DOI: 10.1080/15287394.2013.824395. View

Wolff M, Engel S, Berkowitz G, Ye X, Silva M, Zhu C . Prenatal phenol and phthalate exposures and birth outcomes. Environ Health Perspect. 2008; 116(8):1092-7. PMC: 2516577. DOI: 10.1289/ehp.11007. View

Bloom M, Kim D, Vom Saal F, Taylor J, Cheng G, Lamb J . Bisphenol A exposure reduces the estradiol response to gonadotropin stimulation during in vitro fertilization. Fertil Steril. 2011; 96(3):672-677.e2. PMC: 3168558. DOI: 10.1016/j.fertnstert.2011.06.063. View

Ferguson K, McElrath T, Meeker J . Environmental phthalate exposure and preterm birth. JAMA Pediatr. 2013; 168(1):61-67. PMC: 4005250. DOI: 10.1001/jamapediatrics.2013.3699. View

Braun J, Lanphear B, Calafat A, Deria S, Khoury J, Howe C . Early-life bisphenol a exposure and child body mass index: a prospective cohort study. Environ Health Perspect. 2014; 122(11):1239-45. PMC: 4216170. DOI: 10.1289/ehp.1408258. View

10.

Braveman P, Egerter S, Williams D . The social determinants of health: coming of age. Annu Rev Public Health. 2010; 32:381-98. DOI: 10.1146/annurev-publhealth-031210-101218. View

11.

Ferguson K, McElrath T, Mukherjee B, Loch-Caruso R, Meeker J . Associations between Maternal Biomarkers of Phthalate Exposure and Inflammation Using Repeated Measurements across Pregnancy. PLoS One. 2015; 10(8):e0135601. PMC: 4552851. DOI: 10.1371/journal.pone.0135601. View

12.

Windham G, Pinney S, Sjodin A, Lum R, Jones R, Needham L . Body burdens of brominated flame retardants and other persistent organo-halogenated compounds and their descriptors in US girls. Environ Res. 2010; 110(3):251-7. PMC: 2844779. DOI: 10.1016/j.envres.2010.01.004. View

13.

Nelson M, Gordon-Larsen P, Song Y, Popkin B . Built and social environments associations with adolescent overweight and activity. Am J Prev Med. 2006; 31(2):109-17. DOI: 10.1016/j.amepre.2006.03.026. View

14.

Jacoby V, Fujimoto V, Giudice L, Kuppermann M, Washington A . Racial and ethnic disparities in benign gynecologic conditions and associated surgeries. Am J Obstet Gynecol. 2010; 202(6):514-21. PMC: 4625911. DOI: 10.1016/j.ajog.2010.02.039. View

15.

Lathi R, Liebert C, Brookfield K, Taylor J, Vom Saal F, Fujimoto V . Conjugated bisphenol A in maternal serum in relation to miscarriage risk. Fertil Steril. 2014; 102(1):123-8. PMC: 4711263. DOI: 10.1016/j.fertnstert.2014.03.024. View

16.

Larsson K, Ljung Bjorklund K, Palm B, Wennberg M, Kaj L, Lindh C . Exposure determinants of phthalates, parabens, bisphenol A and triclosan in Swedish mothers and their children. Environ Int. 2014; 73:323-33. PMC: 4207945. DOI: 10.1016/j.envint.2014.08.014. View

17.

Mok-Lin E, Ehrlich S, Williams P, Petrozza J, Wright D, Calafat A . Urinary bisphenol A concentrations and ovarian response among women undergoing IVF. Int J Androl. 2009; 33(2):385-93. PMC: 3089904. DOI: 10.1111/j.1365-2605.2009.01014.x. View

18.

Buck Louis G, Sundaram R, Schisterman E, Sweeney A, Lynch C, Gore-Langton R . Persistent environmental pollutants and couple fecundity: the LIFE study. Environ Health Perspect. 2012; 121(2):231-6. PMC: 3569685. DOI: 10.1289/ehp.1205301. View

19.

Zota A, Linderholm L, Park J, Petreas M, Guo T, Privalsky M . Temporal comparison of PBDEs, OH-PBDEs, PCBs, and OH-PCBs in the serum of second trimester pregnant women recruited from San Francisco General Hospital, California. Environ Sci Technol. 2013; 47(20):11776-84. PMC: 4086273. DOI: 10.1021/es402204y. View

20.

Lu M, Halfon N . Racial and ethnic disparities in birth outcomes: a life-course perspective. Matern Child Health J. 2003; 7(1):13-30. DOI: 10.1023/a:1022537516969. View