Catheter Ablation Targeting Complex Fractionated Atrial Electrogram in Atrial Fibrillation

Overview

Journal J Atr Fibrillation

Date 2017 May 13

PMID 28496893

Citations 3

Authors

Dennis H Lau

Stef Zeemering

Bart Maesen

Pawel Kuklik

Sander Verheule

Ulrich Schotten

Affiliations

Soon will be listed here.

Abstract

The relatively low success rates seen with pulmonary vein ablation in non-paroxysmal atrial fibrillation (AF) patients as compared to those with the paroxysmal form of the arrhythmia have prompted electrophysiologists to search for newer ablative strategies. A decade has passed since the initial description of complex fractionated atrial electrogram (CFAE) ablation aimed at targeting the electrophysiological substrate in atrial fibrillation. Despite intensive research, superiority of CFAE-based ablation over other contemporary approaches could not be demonstrated. Nevertheless, the technique has an adjunctive role to pulmonary vein ablation in non-paroxysmal AF patients. Perhaps our incomplete understanding of the complex AF pathophysiology and inadequate characterization or determination of CFAE has limited our success so far. This review aims to highlight the current challenges and future role of CFAE ablation. .

Citing Articles

Surgery and Catheter Ablation for Atrial Fibrillation: History, Current Practice, and Future Directions.

McCarthy P, Cox J, Kislitsina O, Kruse J, Churyla A, Malaisrie S J Clin Med. 2022; 11(1).

PMID: 35011953 PMC: 8745682. DOI: 10.3390/jcm11010210.

Spatiotemporal characteristics of atrial fibrillation electrograms: A novel marker for arrhythmia stability and termination.

Thanigaimani S, Brooks A, Kuklik P, Twomey D, Franklin S, Noschka E J Arrhythm. 2017; 33(1):40-48.

PMID: 28217228 PMC: 5300869. DOI: 10.1016/j.joa.2016.05.009.

Semi-supervised clustering of fractionated electrograms for electroanatomical atrial mapping.

Orozco-Duque A, Bustamante J, Castellanos-Dominguez G Biomed Eng Online. 2016; 15:44.

PMID: 27117088 PMC: 4845510. DOI: 10.1186/s12938-016-0154-5.

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