Usefulness of Contrast-Enhanced Ultrasonography for Predicting Esophageal Varices in Patients with Hepatitis B Virus (HBV)-Related Cirrhosis

Overview

Journal Med Sci Monit

Specialties General Medicine
Pathology

Date 2017 May 13

PMID 28496092

Citations 2

Authors

Jun Li

Jin-Chun Feng

Xin-Yu Peng

Xiang-Wei Wu

Ting-Ting Du

Jia-Jia Wang

Shu-Xin Tian

Gui-Lin Lu

Affiliations

Soon will be listed here.

Abstract

BACKGROUND The aim of this study was to investigate the usefulness of contrast-enhanced ultrasonography (CEUS) in predicting of esophageal varices (EV) and assessing high-risk EV in patients with hepatitis B virus (HBV)-related cirrhosis. MATERIAL AND METHODS Patients with HBV-related cirrhosis who had undergone endoscopy were prospectively recruited. Hepatic dynamic CEUS was performed. Regions of interest (ROI) were drawn on the hepatic artery, hepatic vein, portal vein, and liver parenchyma to measure the corresponding features, such as arrival times. Spearman's correlation analysis was used to determine the relations between several dynamic CEUS features and the degree of EV. Receiver operating characteristics (ROC) curves were constructed to investigate the diagnostic performance of CEUS in assessing the presence of EV and high-risk EV. RESULTS Fifty-eight patients (44 men; mean age 51.3 years) were included in this study. Of these, 18 (31.0%), 12 (20.7%), 11 (19.0%), and 17 (29.3%) of patients had grade 0, 1, 2, and 3 EV, respectively. Grade 2 and grade 3 EV were considered high-risk EV. Among the CEUS features, the area under the ROC curves of intrahepatic transit time (HV-HA, i.e., the difference between hepatic vein arrival time and hepatic artery arrival time) both for assessment of the presence of EV and high-risk EV (0.883 and 0.915, respectively) were larger than the other indices. HV-HA was negatively correlated with the grade of EV. An HV-HA of under 8.2 s indicated the presence of EV and under 7 s indicated high-risk EV. CONCLUSIONS Dynamic CEUS imaging is useful in assessing the presence of EV and high-risk EV in patients with HBV-related cirrhosis.

Citing Articles

Contrast-enhanced ultrasonography for the management of portal hypertension in cirrhosis.

Maruyama H, Tobari M, Nagamatsu H, Shiina S, Yamaguchi T Front Med (Lausanne). 2023; 9:1057045.

PMID: 36590972 PMC: 9794740. DOI: 10.3389/fmed.2022.1057045.

Contrast-Enhanced Ultrasonography with Arrival Time Parametric Imaging as a Non-Invasive Diagnostic Tool for Liver Cirrhosis.

Lupusoru R, Sporea I, Ratiu I, Lungeanu D, Popescu A, Danila M Diagnostics (Basel). 2022; 12(12).

PMID: 36553020 PMC: 9777167. DOI: 10.3390/diagnostics12123013.

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