» Articles » PMID: 28492522

Impact of Brain Injury on Functional Measures of Amplitude-integrated EEG at Term Equivalent Age in Premature Infants

Overview
Journal J Perinatol
Date 2017 May 12
PMID 28492522
Citations 4
Authors
Affiliations
Soon will be listed here.
Abstract

Objective: To evaluate the association between qualitative and quantitative amplitude-integrated EEG (aEEG) measures at term equivalent age (TEA) and brain injury on magnetic resonance imaging (MRI) in preterm infants.

Study Design: A cohort of premature infants born at <30 weeks of gestation and with moderate-to-severe MRI injury on a TEA MRI scan was identified. A contemporaneous group of gestational age-matched control infants also born at <30 weeks of gestation with none/mild injury on MRI was also recruited. Quantitative aEEG measures, including maximum and minimum amplitudes, bandwidth span and spectral edge frequency (SEF), were calculated using an offline software package. The aEEG recordings were qualitatively scored using the Burdjalov system. MRI scans, performed on the same day as aEEG, occurred at a mean postmenstrual age of 38.0 (range 37 to 42) weeks and were scored for abnormality in a blinded manner using an established MRI scoring system.

Results: Twenty-eight (46.7%) infants had a normal MRI or mild brain abnormality, while 32 (53.3%) infants had moderate-to-severe brain abnormality. Univariate regression analysis demonstrated an association between severity of brain abnormality and quantitative measures of left and right SEF and bandwidth span (β=-0.38, -0.40 and 0.30, respectively) and qualitative measures of cyclicity, continuity and total Burdjalov score (β=-0.10, -0.14 and -0.12, respectively). After correcting for confounding variables, the relationship between MRI abnormality score and aEEG measures of SEF, bandwidth span and Burdjalov score remained significant.

Conclusion: Brain abnormalities on MRI at TEA in premature infants are associated with abnormalities on term aEEG measures, suggesting that anatomical brain injury may contribute to delay in functional brain maturation as assessed using aEEG.

Citing Articles

Early aEEG can predict neurodevelopmental outcomes at 12 to 18 month of age in VLBWI with necrotizing enterocolitis: a cohort study.

Chen S, Xiao X, Lin S, Zhu J, Liang L, Zhu M BMC Pediatr. 2021; 21(1):582.

PMID: 34930183 PMC: 8686651. DOI: 10.1186/s12887-021-03056-6.


Significance of amplitude integrated electroencephalography in early stage of neonatal hypoxic-ischemic encephalopathy and cerebral function monitoring in Neonatal Intensive Care Units.

Pu Y, Zhu Z, Yang Q, Zhang Y, Zhao J, Liu M Am J Transl Res. 2021; 13(8):9437-9443.

PMID: 34540063 PMC: 8430076.


WU-NEAT: A clinically validated, open-source MATLAB toolbox for limited-channel neonatal EEG analysis.

Vesoulis Z, Gamble P, Jain S, Ters N, Liao S, Mathur A Comput Methods Programs Biomed. 2020; 196:105716.

PMID: 32858282 PMC: 7606381. DOI: 10.1016/j.cmpb.2020.105716.


Term-equivalent functional brain maturational measures predict neurodevelopmental outcomes in premature infants.

Ters N, Vesoulis Z, Liao S, Smyser C, Mathur A Early Hum Dev. 2018; 119:68-72.

PMID: 29579560 PMC: 6190680. DOI: 10.1016/j.earlhumdev.2018.02.010.

References
1.
Mukerji A, Shah V, Shah P . Periventricular/Intraventricular Hemorrhage and Neurodevelopmental Outcomes: A Meta-analysis. Pediatrics. 2015; 136(6):1132-43. DOI: 10.1542/peds.2015-0944. View

2.
Olischar M, Klebermass K, Kuhle S, Hulek M, Kohlhauser C, Rucklinger E . Reference values for amplitude-integrated electroencephalographic activity in preterm infants younger than 30 weeks' gestational age. Pediatrics. 2004; 113(1 Pt 1):e61-6. DOI: 10.1542/peds.113.1.e61. View

3.
Kidokoro H, Neil J, Inder T . New MR imaging assessment tool to define brain abnormalities in very preterm infants at term. AJNR Am J Neuroradiol. 2013; 34(11):2208-14. PMC: 4163698. DOI: 10.3174/ajnr.A3521. View

4.
Inder T, Buckland L, Williams C, Spencer C, Gunning M, Darlow B . Lowered electroencephalographic spectral edge frequency predicts the presence of cerebral white matter injury in premature infants. Pediatrics. 2003; 111(1):27-33. DOI: 10.1542/peds.111.1.27. View

5.
Deoni S, Dean 3rd D, Piryatinsky I, OMuircheartaigh J, Waskiewicz N, Lehman K . Breastfeeding and early white matter development: A cross-sectional study. Neuroimage. 2013; 82:77-86. PMC: 3777218. DOI: 10.1016/j.neuroimage.2013.05.090. View